SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis. Cholesterol is one of the main lipids required to preserve the correct cellular function, contributing to the composition of the plasma membrane and participating in transmembrane receptor signalling. Besides these functions, cholesterol is required for the synthesis of steroid hormones, bile acids, oxysterols and vitamin D. Cholesterol levels need to be tightly regulated: in excess, it is toxic to the cell, and the disruption of its homeostasis is associated with various disorders like atherosclerosis and cardiovascular diseases. This review focuses on the role of SUMO in the regulation of proteins involved in the metabolism of cholesterol.

中文翻译：

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SUMOylation可控制胆固醇稳态。

小泛素相关修饰剂（SUMO）进行的SUMOylation蛋白修饰可通过调节各种底物的活性，稳定性，相互作用或亚细胞定位来影响多个细胞过程。SUMO修饰涉及维持代谢稳态所需的大多数细胞过程。胆固醇是保持正确的细胞功能所需的主要脂质之一，有助于细胞质膜的组成并参与跨膜受体信号传导。除了这些功能外，胆固醇还需要合成类固醇激素，胆汁酸，氧固醇和维生素D。胆固醇水平需要严格控制：过量的胆固醇对细胞有毒，其动态平衡的破坏与各种疾病如动脉粥样硬化和心血管疾病有关。这篇综述着重于SUMO在调节胆固醇代谢相关蛋白质中的作用。