CA3-CA1 long-term potentiation (LTP) in the hippocampal slices from juvenile Wistar rats was studied to reveal factors potentially contributing to different sensitivity to neonatal proinflammatory stress (NPS). NPS was induced by intra­peritoneal injections of bacterial lipopolysaccharide (LPS) to neonatal rats (two injections of LPS, or saline in the control group, consecutively on postnatal days 3 and 5 [PND3 and PND5]). In females, a significant effect of NPS on hippocampus development was associated with modifications of long-term synaptic plasticity, the synapses becoming more resistant to LTP induction. LTP deficit in the slices of the NPS group was not associated with a decrease in LTP maintenance, since late LTP generally corresponded to early LTP magnitude, similar in all groups. Moreover, partial correlation revealed significantly higher residual LTP 1 h after high-frequency stimulation in the NPS groups compared to the corresponding value of early LTP in the control groups, suggesting improved consolidation. Both effects were evident in NPS females. A number of males responded to NPS similarly to females, while others were relatively resistant to NPS exposure, a significant increase in variability of LTP magnitude being revealed in NPS males compared to respective females and the control groups. We suggest that postnatal development of long-term plasticity after NPS is similar in animals of both sexes; however, additional specific factor(s) may promote a relative resistance of the male brain.
Dev Neurosci

中文翻译：

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新生儿促炎性应激后，幼年海马的长期增强诱导能力不足，但不能维持。

研究了来自幼年Wistar大鼠海马切片中的CA3-CA1长期增强（LTP），以揭示可能导致对新生儿促炎性应激（NPS）不同敏感性的因素。NPS是通过向新生大鼠腹膜内注射细菌脂多糖（LPS）诱导的（出生后第3天和第5天连续两次注射LPS或对照组的盐水）[PND3和PND5]。在女性中，NPS对海马发育的显着影响与长期突触可塑性的改变有关，突触对LTP的诱导变得更有抵抗力。NPS组切片中的LTP缺乏与LTP维持率降低无关，因为晚期LTP通常对应于早期LTP大小，在所有组中相似。此外，部分相关性显示，与对照组中早期LTP的相应值相比，NPS组在高频刺激后1 h的残余LTP显着更高，这表明固结得以改善。两种作用在NPS雌性中均明显。许多男性对NPS的反应与女性相似，而其他男性则对NPS暴露具有相对的抵抗力，与相应的女性和对照组相比，NPS男性的LTP幅度变异性显着增加。我们建议，NPS后长期可塑性的产后发育在两性动物中是相似的。但是，其他特定因素可能会促进男性大脑的相对抵抗。建议改善合并。两种作用在NPS雌性中均明显。许多男性对NPS的反应与女性相似，而其他男性则对NPS暴露具有相对的抵抗力，与相应的女性和对照组相比，NPS男性的LTP幅度变异性显着增加。我们建议，NPS后长期可塑性的产后发育在两性动物中是相似的。但是，其他特定因素可能会促进男性大脑的相对抵抗。建议改善合并。两种作用在NPS雌性中均明显。许多男性对NPS的反应与女性相似，而其他男性则对NPS暴露具有相对的抵抗力，与相应的女性和对照组相比，NPS男性的LTP幅度变异性显着增加。我们建议，NPS后长期可塑性的产后发育在两性动物中是相似的。但是，其他特定因素可能会促进男性大脑的相对抵抗。我们建议，NPS后长期可塑性的产后发育在两性动物中是相似的。但是，其他特定因素可能会促进男性大脑的相对抵抗。我们建议，NPS后长期可塑性的产后发育在两性动物中是相似的。但是，其他特定因素可能会促进男性大脑的相对抵抗。
开发神经科学