Functional reconstruction of craniomaxillofacial defects is challenging, especially for the patients who suffer from traumatic injury, cranioplasty, and oncologic surgery. Three-dimensional (3D) printing/bioprinting technologies provide a promising tool to fabricate bone tissue engineering constructs with complex architectures and bioactive components. In this study, we implemented multi-material 3D printing to fabricate 3D printed PCL/hydrogel composite scaffolds loaded with dual bioactive small molecules (i.e. resveratrol and strontium ranelate). The incorporated small molecules are expected to target several types of bone cells. We systematically studied the scaffold morphologies and small molecule release profiles. We then investigated the effects of the released small molecules from the drug loaded scaffolds on the behavior and differentiation of mesenchymal stem cells (MSCs), monocyte-derived osteoclasts, and endothelial cells. The 3D printed scaffolds, with and without sm...

中文翻译：

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具有双小分子递送功能的 3D 打印复合支架用于下颌骨再生。


颅颌面缺损的功能重建具有挑战性，特别是对于遭受创伤、颅骨成形术和肿瘤手术的患者。三维（3D）打印/生物打印技术为制造具有复杂结构和生物活性成分的骨组织工程结构提供了一种有前途的工具。在这项研究中，我们采用多材料3D打印来制造负载双生物活性小分子（即白藜芦醇和雷奈酸锶）的3D打印PCL/水凝胶复合支架。掺入的小分子有望靶向多种类型的骨细胞。我们系统地研究了支架形态和小分子释放曲线。然后，我们研究了载药支架释放的小分子对间充质干细胞（MSC）、单核细胞来源的破骨细胞和内皮细胞的行为和分化的影响。 3D 打印支架，有或没有 SM...