Cytoplasmic dynein is an important molecular motor involved in the transport of vesicular and macromolecular cargo along microtubules in cells, often in conjunction with kinesin motors. Dynein is larger and more complex than kinesin and the mechanism and regulation of its movement is currently the subject of intense research. While it was believed for a long time that dynein motors are relatively weak in terms of the force they can generate, recent studies have shown that interactions with regulatory proteins confer large stall forces comparable to those of kinesin. This paper reports on a theoretical study which suggests that these large stall forces may be the result of an emergent, ATP-dependent, bistability resulting in a dynamic catch-bonding behavior that can cause the motor to switch between high and low load-force states.

中文翻译：

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动态捕获键产生细胞质动力蛋白的巨大失速力。

细胞质动力蛋白是一种重要的分子动力，通常与驱动蛋白动力结合，参与沿细胞微管的水泡和大分子货物运输。动力蛋白比动力蛋白更大且更复杂，并且其运动的机理和调控目前是广泛研究的主题。尽管长期以来人们认为动力蛋白产生的力相对较弱，但最近的研究表明，与调节蛋白的相互作用赋予了与驱动蛋白相当的大失速力。本文报告了一项理论研究，该研究表明，这些较大的失速力可能是由依赖于ATP的双稳态现象引起的，从而导致动态的粘扣行为，从而导致电动机在高负载状态和低负载状态之间切换。 。