当前位置: X-MOL 学术Journal of Evidence-Based Medicine › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis.
Journal of Evidence-Based Medicine ( IF 3.6 ) Pub Date : 2020-05-05 , DOI: 10.1111/jebm.12383
Kanhatai Chiengthong 1, 2 , Wisit Cheungpasitporn 3 , Charat Thongprayoon 4 , Ploypin Lertjitbanjong 5 , Liam D Cato 6 , Tarun Bathini 7 , Patompong Ungprasert 8 , Michael A Mao 9 , Ronpichai Chokesuwattanaskul 2, 10
Affiliation  

OBJECTIVE Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. METHODS A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. RESULTS In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. CONCLUSION There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.

中文翻译:

维生素D缺乏与造血干细胞移植后的移植物抗宿主疾病无关:​​一项荟萃分析。

目的维生素D的状态在免疫调节中起着重要作用,据信缺乏与造血干细胞移植(HSCT)患者的移植物抗宿主病(GVHD)有关。我们旨在研究HSCT后维生素D缺乏与GVHD之间的关系。方法从开始到2019年7月,使用MEDLINE,EMBASE和Cochrane图书馆数据库进行文献检索.1临床研究或观察性研究(队列研究,病例对照研究或横断面研究)需要进行合格的研究; 2提供数据计算维生素D缺乏的HSCT患者中GVHD的优势比(OR)。两名审稿人独立提取数据并评估偏见的风险。通过综合荟萃分析3.3软件,使用随机效应荟萃分析估算具有95%置信区间(CI)的合并优势比(OR)。结果该系统评价总共纳入了8项观察性研究,其中包括1335名HSCT患者。总体而言,维生素D缺乏与急性GVHD之间无显着相关性(OR = 1.06,95%CI 0.74-1.53​​,P> 0.05)。维生素D缺乏与慢性GVHD之间无显着相关性(OR = 1.75,95%CI 0.72-4.26,P> 0.05)。进行了漏斗图和Egger回归不对称测试,没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。该系统评价纳入了8项观察性研究,包括1335名HSCT患者。总体而言,维生素D缺乏与急性GVHD之间无显着相关性(OR = 1.06,95%CI 0.74-1.53​​,P> 0.05)。维生素D缺乏与慢性GVHD之间无显着相关性(OR = 1.75,95%CI 0.72-4.26,P> 0.05)。进行了漏斗图和Egger回归不对称测试,没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。该系统评价纳入了8项观察性研究,包括1335名HSCT患者。总体而言,维生素D缺乏与急性GVHD之间无显着相关性(OR = 1.06,95%CI 0.74-1.53​​,P> 0.05)。维生素D缺乏与慢性GVHD之间无显着相关性(OR = 1.75,95%CI 0.72-4.26,P> 0.05)。进行了漏斗图和Egger回归不对称测试,没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。维生素D缺乏与慢性GVHD之间无显着相关性(OR = 1.75,95%CI 0.72-4.26,P> 0.05)。进行了漏斗图和Egger回归不对称测试,没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义的关联。维生素D缺乏与慢性GVHD之间无显着相关性(OR = 1.75,95%CI 0.72-4.26,P> 0.05)。进行了漏斗图和Egger回归不对称测试,没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。
更新日期:2020-05-05
down
wechat
bug