OBJECTIVE Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. METHODS A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. RESULTS In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. CONCLUSION There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.

中文翻译：

---

维生素D缺乏与造血干细胞移植后的移植物抗宿主疾病无关：​​一项荟萃分析。

目的维生素D的状态在免疫调节中起着重要作用，据信缺乏与造血干细胞移植（HSCT）患者的移植物抗宿主病（GVHD）有关。我们旨在研究HSCT后维生素D缺乏与GVHD之间的关系。方法从开始到2019年7月，使用MEDLINE，EMBASE和Cochrane图书馆数据库进行文献检索.1临床研究或观察性研究（队列研究，病例对照研究或横断面研究）需要进行合格的研究; 2提供数据计算维生素D缺乏的HSCT患者中GVHD的优势比（OR）。两名审稿人独立提取数据并评估偏见的风险。通过综合荟萃分析3.3软件，使用随机效应荟萃分析估算具有95％置信区间（CI）的合并优势比（OR）。结果该系统评价总共纳入了8项观察性研究，其中包括1335名HSCT患者。总体而言，维生素D缺乏与急性GVHD之间无显着相关性（OR = 1.06，95％CI 0.74-1.53​​，P> 0.05）。维生素D缺乏与慢性GVHD之间无显着相关性（OR = 1.75，95％CI 0.72-4.26，P> 0.05）。进行了漏斗图和Egger回归不对称测试，没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。该系统评价纳入了8项观察性研究，包括1335名HSCT患者。总体而言，维生素D缺乏与急性GVHD之间无显着相关性（OR = 1.06，95％CI 0.74-1.53​​，P> 0.05）。维生素D缺乏与慢性GVHD之间无显着相关性（OR = 1.75，95％CI 0.72-4.26，P> 0.05）。进行了漏斗图和Egger回归不对称测试，没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。该系统评价纳入了8项观察性研究，包括1335名HSCT患者。总体而言，维生素D缺乏与急性GVHD之间无显着相关性（OR = 1.06，95％CI 0.74-1.53​​，P> 0.05）。维生素D缺乏与慢性GVHD之间无显着相关性（OR = 1.75，95％CI 0.72-4.26，P> 0.05）。进行了漏斗图和Egger回归不对称测试，没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。维生素D缺乏与慢性GVHD之间无显着相关性（OR = 1.75，95％CI 0.72-4.26，P> 0.05）。进行了漏斗图和Egger回归不对称测试，没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义的关联。维生素D缺乏与慢性GVHD之间无显着相关性（OR = 1.75，95％CI 0.72-4.26，P> 0.05）。进行了漏斗图和Egger回归不对称测试，没有发现偏倚。结论维生素D缺乏与急性和慢性GVHD均无统计学意义。