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New simple molecular fluorescent probes for rapid and highly selective sensing of hydrazine by aggregate-induced emission.
Analyst ( IF 3.6 ) Pub Date : 2020-05-21 , DOI: 10.1039/d0an00601g
B B Pavankumar 1 , Prabodh Ranjan , Prakash C Jha , Akella Sivaramakrishna
Affiliation  

With an aim towards the design of efficient and straightforward fluorescent probes for hydrazine, the synthesis of (2-acetoxyaryl) methylene diacetate derivatives (1–4) was carried out by reacting substituted aromatic α-hydroxy aldehydes with acetyl chloride and sodium acetate in excellent yields. As a preliminary investigation, the ability of probe 1 was examined for the detection of substituted aliphatic and aromatic amines, amino acids, and other ions in Britton–Robinson buffer solution (50 mM, water/ethanol v/v of 99/1 at pH 7.4). Probe 1 selectively exhibited an intense blue fluorescence with hydrazine in less than 2 minutes, whereas light green or no fluorescence was noticed with substituted amines and amino acids. Among all the probes employed (1–4) in the present study, probes 1 and 2 were found efficient towards the rapid detection of hydrazine. Furthermore, the fluorescence sensing ability of probes 1 and 2 was tested not only under varying pH conditions but also by varying water-fraction from 0–99%. Moreover, the detection limits of hydrazine using 1 and 2 were found as 8.4 and 8.7 ppb, respectively, which is less than the acceptable limit as per the standards of the US Environment Protection Agency. In this contribution, the probes 1 and 2 demonstrate rapid, selective, sensitive, and ratiometric detection of highly toxic hydrazine by OFF–ON fluorescence switch in water samples as well as living cells.

中文翻译:

新的简单分子荧光探针,可通过聚集体诱导的发射来快速,高度选择性地检测肼。

为了设计高效,简单的肼荧光探针,通过使取代的芳族α-羟基醛与乙酰氯和乙酸钠在极好的条件下反应,进行了(2-乙酰氧基芳基)亚甲基二乙酸酯衍生物(1-4)的合成。产量。作为初步研究,检查了探针1检测Britton-Robinson缓冲溶液(50 mM,水/乙醇v / v在pH为99/1时)中取代的脂肪族和芳香族胺,氨基酸和其他离子的能力7.4)。探针1在不到2分钟的时间内用肼选择性地显示出强烈的蓝色荧光,而在被取代的胺和氨基酸的作用下,没有发现浅绿色或没有荧光。在所有使用的探针中(1-4)在本研究中,发现探针12对快速检测肼有效。此外,不仅在变化的pH条件下,而且在0-99%的水馏分下测试了探针12的荧光传感能力。此外,使用12检出的肼的检出限分别为8.4 ppb和8.7 ppb,这低于美国环境保护署的标准所接受的极限。在此贡献中,探针12 演示了通过OFF-ON荧光开关在水样以及活细胞中快速,选择性,灵敏和按比例测定高毒性肼的方法。
更新日期:2020-06-29
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