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New simple molecular fluorescent probes for rapid and highly selective sensing of hydrazine by aggregate-induced emission.
Analyst ( IF 3.6 ) Pub Date : 2020-05-21 , DOI: 10.1039/d0an00601g B B Pavankumar 1 , Prabodh Ranjan , Prakash C Jha , Akella Sivaramakrishna
Analyst ( IF 3.6 ) Pub Date : 2020-05-21 , DOI: 10.1039/d0an00601g B B Pavankumar 1 , Prabodh Ranjan , Prakash C Jha , Akella Sivaramakrishna
Affiliation
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With an aim towards the design of efficient and straightforward fluorescent probes for hydrazine, the synthesis of (2-acetoxyaryl) methylene diacetate derivatives (1–4) was carried out by reacting substituted aromatic α-hydroxy aldehydes with acetyl chloride and sodium acetate in excellent yields. As a preliminary investigation, the ability of probe 1 was examined for the detection of substituted aliphatic and aromatic amines, amino acids, and other ions in Britton–Robinson buffer solution (50 mM, water/ethanol v/v of 99/1 at pH 7.4). Probe 1 selectively exhibited an intense blue fluorescence with hydrazine in less than 2 minutes, whereas light green or no fluorescence was noticed with substituted amines and amino acids. Among all the probes employed (1–4) in the present study, probes 1 and 2 were found efficient towards the rapid detection of hydrazine. Furthermore, the fluorescence sensing ability of probes 1 and 2 was tested not only under varying pH conditions but also by varying water-fraction from 0–99%. Moreover, the detection limits of hydrazine using 1 and 2 were found as 8.4 and 8.7 ppb, respectively, which is less than the acceptable limit as per the standards of the US Environment Protection Agency. In this contribution, the probes 1 and 2 demonstrate rapid, selective, sensitive, and ratiometric detection of highly toxic hydrazine by OFF–ON fluorescence switch in water samples as well as living cells.
中文翻译：
新的简单分子荧光探针，可通过聚集体诱导的发射来快速，高度选择性地检测肼。
为了设计高效，简单的肼荧光探针，通过使取代的芳族α-羟基醛与乙酰氯和乙酸钠在极好的条件下反应，进行了（2-乙酰氧基芳基）亚甲基二乙酸酯衍生物（1-4）的合成。产量。作为初步研究，检查了探针1检测Britton-Robinson缓冲溶液（50 mM，水/乙醇v / v在pH为99/1时）中取代的脂肪族和芳香族胺，氨基酸和其他离子的能力7.4）。探针1在不到2分钟的时间内用肼选择性地显示出强烈的蓝色荧光，而在被取代的胺和氨基酸的作用下，没有发现浅绿色或没有荧光。在所有使用的探针中（1-4）在本研究中，发现探针1和2对快速检测肼有效。此外，不仅在变化的pH条件下，而且在0-99％的水馏分下测试了探针1和2的荧光传感能力。此外，使用1和2检出的肼的检出限分别为8.4 ppb和8.7 ppb，这低于美国环境保护署的标准所接受的极限。在此贡献中，探针1和2 演示了通过OFF-ON荧光开关在水样以及活细胞中快速，选择性，灵敏和按比例测定高毒性肼的方法。
更新日期：2020-06-29
中文翻译：
新的简单分子荧光探针，可通过聚集体诱导的发射来快速，高度选择性地检测肼。
为了设计高效，简单的肼荧光探针，通过使取代的芳族α-羟基醛与乙酰氯和乙酸钠在极好的条件下反应，进行了（2-乙酰氧基芳基）亚甲基二乙酸酯衍生物（1-4）的合成。产量。作为初步研究，检查了探针1检测Britton-Robinson缓冲溶液（50 mM，水/乙醇v / v在pH为99/1时）中取代的脂肪族和芳香族胺，氨基酸和其他离子的能力7.4）。探针1在不到2分钟的时间内用肼选择性地显示出强烈的蓝色荧光，而在被取代的胺和氨基酸的作用下，没有发现浅绿色或没有荧光。在所有使用的探针中（1-4）在本研究中，发现探针1和2对快速检测肼有效。此外，不仅在变化的pH条件下，而且在0-99％的水馏分下测试了探针1和2的荧光传感能力。此外，使用1和2检出的肼的检出限分别为8.4 ppb和8.7 ppb，这低于美国环境保护署的标准所接受的极限。在此贡献中，探针1和2 演示了通过OFF-ON荧光开关在水样以及活细胞中快速，选择性，灵敏和按比例测定高毒性肼的方法。
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