Background Peripheral arterial disease is associated with increased cardiovascular mortality and morbidity. C-reactive protein and albumin are biomarkers of inflammation and malnutrition that play key roles in the pathophysiological pathways involved in the progression of atherosclerosis and peripheral arterial disease. In this study, we aimed to assess the relationship between C-reactive protein to albumin ratio and the suprapopliteal peripheral arterial disease severity and complexity as assessed by TransAtlantic Inter-Society Consensus-II (TASC-II) classification. Method Our study enrolled 224 consecutive patients referred for peripheral angiography with the clinical features of possible peripheral arterial disease at a tertiary care center between January 2016 and September 2019. Level of disease and lesion characteristics were defined with reference to angiographic findings according to the TASC-II classification. Results C-reactive protein/albumin ratio levels were significantly higher in TASC-II class C and D than in TASC-II class B patients with a median level of 1.8 to 2.1 vs 1.4, respectively (p = 0.018). In multivariate regression analysis, C-reactive protein to albumin ratio remained an independent predictor of severe peripheral arterial disease. The predictive performance of C-reactive protein to albumin ratio, C-reactive protein, and albumin were compared by Receiver Operating Characteristic curve analysis. C-reactive protein to albumin ratio surpassed C-reactive protein and albumin in predicting peripheral arterial disease severity and complexity. A level of C-reactive protein to albumin ratio > 0.14 predicted a higher grade of suprapopliteal TASC-II class with sensitivity and specificity of 68.2% and 56.0%, respectively. Conclusion C-reactive protein to albumin ratio was strongly associated with peripheral arterial disease severity and complexity, as assessed by TASC-II classification. Also, C-reactive protein to albumin ratio was found to be a more accurate marker than C-reactive protein and albumin alone in predicting more severe and complex lesions in patients with peripheral arterial disease.

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评估 C 反应蛋白与白蛋白的比率与外周动脉疾病的严重程度和复杂性之间的关系

背景外周动脉疾病与心血管死亡率和发病率增加有关。C 反应蛋白和白蛋白是炎症和营养不良的生物标志物，它们在参与动脉粥样硬化和外周动脉疾病进展的病理生理学途径中起关键作用。在这项研究中，我们旨在评估 C 反应蛋白与白蛋白的比率与跨大西洋社会间共识-II (TASC-II) 分类评估的腘上外周动脉疾病严重程度和复杂性之间的关系。方法 我们的研究在 2016 年 1 月至 2019 年 9 月期间在三级医疗中心招募了 224 名连续接受外周血管造影的患者，这些患者具有可能的外周动脉疾病的临床特征。根据 TASC-II 分类，参照血管造影结果定义疾病水平和病变特征。结果 TASC-II C 类和 D 类患者的 C 反应蛋白/白蛋白比率水平显着高于 TASC-II B 类患者，中位水平分别为 1.8 至 2.1 和 1.4（p = 0.018）。在多元回归分析中，C 反应蛋白与白蛋白的比率仍然是严重外周动脉疾病的独立预测因子。C-反应蛋白与白蛋白比率、C-反应蛋白和白蛋白的预测性能通过接受者操作特征曲线分析进行比较。C-反应蛋白与白蛋白的比率在预测外周动脉疾病的严重程度和复杂性方面超过了 C-反应蛋白和白蛋白。C 反应蛋白与白蛋白的比率水平 > 0。14 预测腘上 TASC-II 等级更高，敏感性和特异性分别为 68.2% 和 56.0%。结论 根据 TASC-II 分类评估，C 反应蛋白与白蛋白的比率与外周动脉疾病的严重程度和复杂性密切相关。此外，在预测外周动脉疾病患者更严重和更复杂的病变方面，C-反应蛋白与白蛋白的比率被发现是比单独的 C-反应蛋白和白蛋白更准确的标志物。