Cilia play an important role in the airway defense mechanism. So far, studies on ciliary function have mainly been based on in vitro methods. Images of in vivo ciliary motion are very difficult to capture. In this study, we describe a novel approach to observe and analyze nasal ciliary motion in living animals with comparison to in vitro observation. Such images of ciliary motion from living animals have not been reported to date. The result of the study indicates that in vivo ciliary physiological function differs from ex vivo and in vitro conditions in many ways, such as the stability over time and response to temperature variation. This is a good foundation for further in vivo analysis of airway ciliary physiological function in animals as well as humans.

中文翻译：

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在豚鼠模型中体内和体外观察鼻睫状运动。

纤毛在气道防御机制中起着重要作用。迄今为止，关于睫状功能的研究主要基于体外方法。体内睫状运动的图像很难捕获。在这项研究中，我们描述了一种与体外观察相比观察和分析活体动物鼻睫状运动的新颖方法。迄今为止尚未报道过这种来自活体动物的纤毛运动的图像。研究结果表明，体内睫状体生理功能在许多方面与离体和体外条件不同，例如随时间的稳定性和对温度变化的响应。这为进一步体内分析动物和人类气道纤毛生理功能奠定了良好的基础。