Hyperpolarized Magnetic Resonance of Exchangeable Protons Using Parahydrogen and Aminosilane,The Journal of Physical Chemistry C

当前位置： X-MOL 学术 › J. Phys. Chem. C › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hyperpolarized Magnetic Resonance of Exchangeable Protons Using Parahydrogen and Aminosilane
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2020-05-21 , DOI: 10.1021/acs.jpcc.0c01149
Ewoud Vaneeckhaute ₁ , Jean-Max Tyburn ₂ , David Kilgour ₂ , James G. Kempf ₃ , Francis Taulelle ₄ , Johan A. Martens ₄ , Eric Breynaert ₁

Affiliation

Efficient, room temperature hyperpolarization of exchangeable solvent protons combining parahydrogen (p-H₂), aminopropyldiethoxymethylsilane (APDMS), and IrCl(COD)(IMes) to generate an active aminosilane–iridium complex broadens the capabilities of signal amplification by reversible exchange (SABRE)-type hyperpolarization of protons. A primary pool of hyperpolarized exchangeable protons transfers its hyperpolarization to cosolutes with labile protons, partly overcoming the catalytic specificity of SABRE-type spin-transfer catalysis. The silane functionality of APDMS appears to be crucial to its improvement. Its role is unprecedented in p-H₂-based hyperpolarization of nuclear spins and promises to broaden its applicability of ultrasensitive solution-state NMR spectroscopy for the detection and elucidation of molecular behavior, at concentrations undetectable by conventional NMR spectroscopy.

中文翻译：

使用对氢和氨基硅烷的可交换质子的超极化磁共振

高效，可交换溶剂质子的室温超极化，结合了对氢（p -H ₂），氨丙基_二乙氧基甲基硅烷（APDMS）和IrCl（COD）（IMes）生成活性氨基硅烷-铱络合物，通过可逆交换（SABRE）扩大了信号放大的能力）型质子超极化。超极化可交换质子的主要池将其超极化转移至具有不稳定质子的固溶体，部分克服了SABRE型自旋转移催化的催化特异性。APDMS的硅烷官能度似乎对其改善至关重要。它在p -H _2中的作用是空前的核自旋的超极化技术，有望扩大其在超灵敏的溶液态NMR光谱学中的检测和阐明分子行为的适用性，而这种浓度在常规NMR光谱学无法检测到。

更新日期：2020-07-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11