Constructing Thermally Reversible Dynamic Hydrogels via Catalysis-Free Knoevenagel Condensation,ACS Macro Letters

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Constructing Thermally Reversible Dynamic Hydrogels via Catalysis-Free Knoevenagel Condensation
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-05-21 , DOI: 10.1021/acsmacrolett.0c00330
Xiaoya Ding _{1,

2} , Gao Li _{1,

2} , Peng Zhang _{1,

3} , Chunsheng Xiao _{1,

3}

Affiliation

Thermally reversible dynamic covalent bonds (TRDCBs) have attracted great interest for building polymers with self-healing and adaptable properties in bulk. However, none of the developed TRDCBs can be used in aqueous media for the fabrication of thermally reversible dynamic hydrogels due to the requirement of high temperature to initiate the retro-reaction or the susceptibility to hydrolysis. Herein, we report a thermally reversible dynamic covalent C═C double bond that was formed by catalysis-free Knoevenagel condensation (CKC) between benzaldehyde and cyanoacetate end-functionalized polymers in aqueous solution. The as-formed TRDCB shows typical thermal reversibility in the aqueous media under mild temperatures (4–70 °C). Constructing hydrogels with this TRDCB led to the formation of thermally reversible dynamic hydrogels with intriguing self-healing, injectable, thermosensitive, and thermoplastic properties. Overall, this work not only broadens the application of TRDCBs in aqueous media but also provides a thermally reversible dynamic hydrogel for potential use in various biomedical fields.

中文翻译：

通过无催化 Knoevenagel 缩合构建热可逆动态水凝胶

热可逆动态共价键（TRDCBs）在构建具有自愈性和适应性的聚合物散装聚合物方面引起了极大的兴趣。然而，由于需要高温来引发逆反应或对水解的敏感性，已开发的 TRDCB 均不能用于水介质中制备热可逆动态水凝胶。在此，我们报道了一种热可逆的动态共价 C=C 双键，它是由苯甲醛和氰基乙酸酯末端官能化聚合物在水溶液中的无催化 Knoevenagel 缩合 (CKC) 形成的。形成的 TRDCB 在温和温度（4-70 °C）下在水介质中显示出典型的热可逆性。用这种 TRDCB 构建水凝胶导致形成具有有趣的自愈、可注射、热敏和热塑性特性的热可逆动态水凝胶。总体而言，这项工作不仅拓宽了 TRDCB 在水介质中的应用，而且还提供了一种热可逆动态水凝胶，可用于各种生物医学领域。

更新日期：2020-05-21

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