Abnormal long noncoding RNAs (lncRNAs) participate in the generation and progression of malignancies. We aimed to determine the expression and clinical importance of lncRNA ENST433110 in thyroid cancer (TC). We thus investigated the role of ENST433110 in TC cell invasion, migration, and proliferation. ENST433110 expression was assessed using RT-PCR, cell migration was evaluated using a Transwell assay, and cell apoptosis was analyzed by flow cytometry. Our findings revealed that ENST433110 expression was dramatically reduced in TC sample tissues and TC cells (B-CPAP and TPC-1). Moreover, we showed that lncRNA ENST433110 overexpression inhibited cell migration and proliferation in TC cells. Furthermore, lncRNA ENST433110 overexpression enhanced cell apoptosis and induced a noticeable reduction in Bcl-2 expression and an increase in BAX expression in both TPC-1 and B-CPAP cells compared with that in control groups. In summary, our results indicate that lncRNA ENST433110 is important in the development of thyroid carcinoma and could thus be a promising target in thyroid carcinoma treatment.

异常的长非编码RNA（lncRNA）参与了恶性肿瘤的发生和发展。我们旨在确定lncRNA ENST433110在甲状腺癌（TC）中的表达及其临床意义。因此，我们研究了ENST433110在TC细胞入侵，迁移和增殖中的作用。使用RT-PCR评估ENST433110的表达，使用Transwell测定法评估细胞迁移，并通过流式细胞术分析细胞凋亡。我们的发现表明，在TC样本组织和TC细胞（B-CPAP和TPC-1）中ENST433110表达显着降低。此外，我们表明lncRNA ENST433110过表达抑制了TC细胞中的细胞迁移和增殖。此外，与对照组相比，lncRNA ENST433110过表达增强了细胞凋亡，并诱导了TPC-1和B-CPAP细胞中Bcl-2表达的明显减少和BAX表达的增加。总之，我们的结果表明，lncRNA ENST433110在甲状腺癌的发展中很重要，因此可能成为甲状腺癌治疗中有希望的靶标。