Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.

中文翻译：

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具有人性化肺和免疫系统的小鼠 - COVID-19 和其他呼吸道疾病的理想模型。


严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)（导致 COVID-19 大流行病的病原体）缺乏合适的动物模型来研究，这在了解疾病生物学以及评估治疗和预防候选药物的过程中遇到了重大障碍。现在是公共卫生机构重新审视人类多能干细胞移植监管的时候了，以期开发具有人源化肺的人源化小鼠模型。