Abstract

The aim of this study was to investigate the prognostic values of a novel evaluated system, named the CONN (combination of Nutritional Risk Screening 2002 [NRS-2002] and neutrophil-to-lymphocyte ratio [NLR]), in patients with esophageal squamous cell carcinoma (ESCC) by curative esophagectomy. A total of 278 patients with ESCC receiving standard curative esophagectomy were retrospectively analyzed. The CONN was calculated by combined NRS-2002 and NLR according to the corresponding cutoff values: patients with both elevated NRS-2002 (≥3.0) and NLR (≥3.0) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. In our univariate analysis, the following factors were significantly associated with poor PFS and OS: T stage, N stage, TNM stage, NLR, NRS-2002 and CONN (all P < 0.05). Furthermore, multivariate Cox regression analysis showed that N stage (P = 0.039), NRS-2002 (P = 0.041) and CONN (P = 0.001) were independent prognostic factors for PFS. While T stage (P = 0.017), N stage (P = 0.048), NLR (P = 0.021), NRS-2002 (P = 0.001) and CONN (P = 0.001) were independent prognostic factors for OS. In conclusion, CONN was an independent prognostic marker for survival prediction in patients with ESCC receiving surgery.

摘要

本研究的目的是调查名为 CONN（营养风险筛查 2002 [NRS-2002] 和中性粒细胞与淋巴细胞比率 [NLR] 的组合）的新型评估系统在食管鳞状细胞癌患者中的预后价值。通过根治性食管切除术治疗癌 (ESCC)。对 278 名接受标准根治性食管切除术的 ESCC 患者进行回顾性分析。CONN 由 NRS-2002 和 NLR 根据相应的截止值组合计算：NRS-2002（≥3.0）和 NLR（≥3.0）均升高的患者分配 2 分，显示两者之一或两者均不升高的患者分配分别为 1 或 0 分。在我们的单变量分析中，以下因素与较差的 PFS 和 OS 显着相关：T 分期、N 分期、TNM 分期、NLR、NRS-2002 和 CONN（所有P < 0.05)。此外，多变量Cox回归分析显示N分期（P  = 0.039）、NRS-2002（P  = 0.041）和CONN（P  = 0.001）是PFS的独立预后因素。而T分期（P  =0.017）、N分期（P  =0.048）、NLR（P  =0.021）、NRS-2002（P  =0.001）和CONN（P  =0.001）是OS的独立预后因素。总之，CONN是接受手术的ESCC患者生存预测的独立预后标志物。