当前位置: X-MOL 学术Nutr. Cancer › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Combination of Preoperative Nutritional Risk Screening-2002 and Neutrophil-to-Lymphocyte Ratio is a Useful Prognostic Marker in Patients with Esophageal Squamous Cell Carcinoma
Nutrition and Cancer ( IF 2.0 ) Pub Date : 2020-05-21 , DOI: 10.1080/01635581.2020.1766090
Xin-Wei Guo 1 , Ju-Ying Zhou 2 , Wei Jiang 3 , Lei Ji 2 , Yang-Chen Liu 1 , Xiao-Xiang Yin 1
Affiliation  

Abstract

The aim of this study was to investigate the prognostic values of a novel evaluated system, named the CONN (combination of Nutritional Risk Screening 2002 [NRS-2002] and neutrophil-to-lymphocyte ratio [NLR]), in patients with esophageal squamous cell carcinoma (ESCC) by curative esophagectomy. A total of 278 patients with ESCC receiving standard curative esophagectomy were retrospectively analyzed. The CONN was calculated by combined NRS-2002 and NLR according to the corresponding cutoff values: patients with both elevated NRS-2002 (≥3.0) and NLR (≥3.0) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. In our univariate analysis, the following factors were significantly associated with poor PFS and OS: T stage, N stage, TNM stage, NLR, NRS-2002 and CONN (all P < 0.05). Furthermore, multivariate Cox regression analysis showed that N stage (P = 0.039), NRS-2002 (P = 0.041) and CONN (P = 0.001) were independent prognostic factors for PFS. While T stage (P = 0.017), N stage (P = 0.048), NLR (P = 0.021), NRS-2002 (P = 0.001) and CONN (P = 0.001) were independent prognostic factors for OS. In conclusion, CONN was an independent prognostic marker for survival prediction in patients with ESCC receiving surgery.



中文翻译:

术前营养风险筛查 2002 和中性粒细胞与淋巴细胞比率的组合是食管鳞状细胞癌患者有用的预后标志物

摘要

本研究的目的是调查名为 CONN(营养风险筛查 2002 [NRS-2002] 和中性粒细胞与淋巴细胞比率 [NLR] 的组合)的新型评估系统在食管鳞状细胞癌患者中的预后价值。通过根治性食管切除术治疗癌 (ESCC)。对 278 名接受标准根治性食管切除术的 ESCC 患者进行回顾性分析。CONN 由 NRS-2002 和 NLR 根据相应的截止值组合计算:NRS-2002(≥3.0)和 NLR(≥3.0)均升高的患者分配 2 分,显示两者之一或两者均不升高的患者分配分别为 1 或 0 分。在我们的单变量分析中,以下因素与较差的 PFS 和 OS 显着相关:T 分期、N 分期、TNM 分期、NLR、NRS-2002 和 CONN(所有P < 0.05)。此外,多变量Cox回归分析显示N分期(P  = 0.039)、NRS-2002(P  = 0.041)和CONN(P  = 0.001)是PFS的独立预后因素。而T分期(P  =0.017)、N分期(P  =0.048)、NLR(P  =0.021)、NRS-2002(P  =0.001)和CONN(P  =0.001)是OS的独立预后因素。总之,CONN是接受手术的ESCC患者生存预测的独立预后标志物。

更新日期:2020-05-21
down
wechat
bug