Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.

中文翻译：

---

异烟肼的静电纺丝口腔分散膜，用于小儿肺结核的治疗。

适合儿童的剂型对于促进儿科患者尤其是在资源匮乏地区进行长期治疗的患者的依从性和有效的药物治疗至关重要。本研究的目的是开发用于对患有肺结核的儿童进行异烟肼给药的口腔分散膜（ODF）。使用静电纺丝法从天然和半合成聚合物共混物的水溶液中生产ODF。对纺丝溶液和所得纤维进行了物理化学表征，并在模拟唾液中评估了ODF的崩解时间和异烟肼释放。ODF由具有足够的热稳定性和可能的​​药物非晶化的纳米纤维组成。与唾液模拟接触后不到15 s，薄膜立即崩解，在崩解后，ODF和异烟肼在相同的介质中从ODF中释放出来，在不到60 s的时间内实现了快速，完全的药物释放。ODF的易于给药以及有利的药物装载和释放性质可以提供剂型，该剂型能够促进对儿科患者群体内治疗的适当依从性。