The study aims to assess the impact of age, pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID) in horses on selected oxidative stress markers. The study includes 32 horses, divided into three groups: “young” adult group (aged 8–16 years old) “geriatric” group (aged 18–24 years old) and the “PPID” group (aged 15–31 years old). The PPID group was further divided into two subgroups: PPID ID+ and PPID ID− based on presence or absence of ID. We measured serum antioxidant stress markers in all horses: total oxidant status (TOS), total antioxidant capacity (TAC), ceruloplasmin (CER), lipofuscin (LPS), malondialdehyde (MDA) and thiols concentrations (containing sulfhydryl group -SH) as well as enzymatic systems: total superoxide dismutase (SOD), cytoplasmic SOD (CuZnSOD), mitochondrial SOD activity (MnSOD). Total serum thiols were significantly lower in the geriatric group and in the PPID group compared to the young group. The MnSOD concentration was higher in the PPID ID+ group compared to the PPID ID−. LPS and MDA concentrations were lower in the PPID ID+ group compared to the PPID ID− group. In the selected study groups of horses, older age, the presence of PPID and ID in the case of PPID had no effect on the studied oxidative stress markers.

中文翻译：

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晚期年龄，垂体pars中间功能障碍和胰岛素调节异常对马血清抗氧化指标的影响。

这项研究旨在评估年龄，垂体中间部分功能障碍（PPID）和胰岛素失调（ID）对选定的氧化应激标志物的影响。该研究包括32匹马，分为三组：“年轻”成年组（8-16岁），“老年”组（18-24岁）和“ PPID”组（15-31岁）。 。根据ID的存在或不存在，PPID组进一步分为两个子组：PPID ID +和PPID ID-。我们测量了所有马匹的血清抗氧化剂应激指标：总氧化剂状态（TOS），总抗氧化剂容量（TAC），铜蓝蛋白（CER），脂褐素（LPS），丙二醛（MDA）和硫醇浓度（含巯基-SH）作为酶系统：总超氧化物歧化酶（SOD），细胞质SOD（CuZnSOD），线粒体SOD活性（MnSOD）。与年轻组相比，老年组和PPID组的总血清硫醇含量显着降低。与PPID ID-相比，PPID ID +组中的MnSOD浓度更高。与PPID ID-组相比，PPID ID +组中的LPS和MDA浓度较低。在选定的年龄较大的马研究组中，PPID的情况下PPID和ID的存在对所研究的氧化应激标记没有影响。