Mechanism of interaction between hydroxypropyl cellulose and water in aqueous solutions: Importance of polymer chain length,Journal of Polymer Science

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Mechanism of interaction between hydroxypropyl cellulose and water in aqueous solutions: Importance of polymer chain length
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-05-21 , DOI: 10.1002/pol.20200185
Manuel Martin‐Pastor ₁ , Edmont Stoyanov ₂

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The utilization of hydroxypropyl cellulose (HPC) can be regarded as unexpected with regard to certain applications, such as being employed as a solubility enhancer for poorly soluble drugs and as a solubilizing agent for nano‐suspensions and amorphous solid dispersions. However, the best results were obtained for low‐molecular weight (M_w) HPC grades with a short‐chain structure. Therefore, in this study, seven grades of HPC with different polymer chain lengths (M_w) are analyzed in various aqueous solutions by a combination of ¹H quantitative NMR spectroscopy, diffusion NMR spectroscopy, and water ligand observed via gradient spectroscopy; these investigations provide insights into the remarkable solubilizing property of HPC at the molecular and supramolecular levels. Furthermore, the hydration and the water residence time are found to be strongly dependent on the polymer chain length of HPC. The quantitative results obtained herein indicate that HPCs with shorter chain lengths retain smaller amounts of water around their hydrated molecules, as compared to their counterparts with longer chain lengths.

中文翻译：

羟丙基纤维素与水溶液之间的相互作用机理：聚合物链长的重要性

在某些应用中，羟丙基纤维素（HPC）的使用可能被认为是出乎意料的，例如用作难溶性药物的溶解度增强剂和纳米悬浮液和无定形固体分散体的增溶剂。但是，对于具有短链结构的低分子量（M _w）HPC级，则获得了最佳结果。因此，在这项研究中，通过在不同的水溶液中分析^1种化合物，分析了7种具有不同聚合物链长（M _w）的HPC 。通过梯度光谱法观察到的H定量NMR光谱，扩散NMR光谱和水配体; 这些研究提供了对HPC在分子和超分子水平上非凡的增溶性能的见解。此外，发现水合和水停留时间强烈依赖于HPC的聚合物链长。本文获得的定量结果表明，与链长较长的HPC相比，链长较短的HPC在其水合分子周围保留的水量较少。

更新日期：2020-05-21

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