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Ameliorating Activity of Ishige okamurae on the Amyloid Beta-Induced Cognitive Deficits and Neurotoxicity through Regulating ERK, p38 MAPK, and JNK Signaling in Alzheimer's Disease-Like Mice Model.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-03 , DOI: 10.1002/mnfr.201901220
Oh Yun Kwon 1 , Seung Ho Lee 1
Affiliation  

Alzheimer's disease (AD) is associated with amyloid beta peptide (Aβ25‐35) accumulation in brains, which induces neurotoxicity and cognitive impairment. The effects of Ishige okamurae, an edible brown algae, on Aβ25‐35‐induced cognitive impairment and neuronal toxicity is investigated. The aim of this study is to determine the molecular mechanisms responsible for I. okamurae extracts (IOE) mediating anti‐AD effects.

中文翻译:


Ishige okamurae 通过调节阿尔茨海默病样小鼠模型中的 ERK、p38 MAPK 和 JNK 信号传导来改善淀粉样蛋白诱导的认知缺陷和神经毒性。



阿尔茨海默病 (AD) 与大脑中淀粉样蛋白肽 (Aβ 25-35 ) 的积累有关,从而引起神经毒性和认知障碍。研究了Ishige okamurae (一种可食用褐藻)对 Aβ 25-35诱导的认知障碍和神经元毒性的影响。本研究的目的是确定冈村豆提取物 (IOE) 介导抗 AD 作用的分子机制。
更新日期:2020-06-03
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