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Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-05-21 , DOI: 10.1111/nmo.13875
Walter Morales 1 , Konstantinos Triantafyllou 2 , Gonzalo Parodi 1 , Stacy Weitsman 1 , Sung Chul Park 1, 3 , Ali Rezaie 1 , Nipaporn Pichetshote 1 , Eugenia Lin 1 , Mark Pimentel 1
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Recent data substantiate the importance of acute gastroenteritis in the development of irritable bowel syndrome (IBS). An animal model of postinfectious IBS determined the importance of cytolethal distending toxin B (CdtB) during live Campylobacter jejuni infection and its development of autoimmunity to vinculin. In this study, we examine whether subcutaneous exposure to CdtB alone is sufficient to produce the postinfectious IBS effect and autoimmunity.

中文翻译:

在感染后肠易激综合征的大鼠模型中,用细胞致死膨胀毒素 B 进行免疫接种会产生针对纽蛋白和小肠细菌变化的自身抗体。

最近的数据证实了急性胃肠炎在肠易激综合征 (IBS) 发展中的重要性。感染后 IBS 的动物模型确定了细胞致死膨胀毒素 B (CdtB) 在空肠弯曲杆菌感染及其对纽蛋白的自身免疫发展过程中的重要性。在这项研究中,我们检查了单独皮下暴露于 CdtB 是否足以产生感染后 IBS 效应和自身免疫。
更新日期:2020-05-21
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