Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice.,Journal of Cellular Physiology

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Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-21 , DOI: 10.1002/jcp.29791
Katherine Forman _{1,

2} , Fernando Martínez _{1,

3} , Manuel Cifuentes ₄ , Marcos Fernández ₅ , Romina Bertinat _{1,

3} , Pablo Torres ₅ , Katterine Salazar _{1,

3} , Alejandro Godoy _{6,

7} , Francisco Nualart _{1,

3}

Affiliation

Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age‐related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues and has different metabolism and uptake. In this study, we analyzed the antiaging effect of vitamin C, both oxidized and reduced forms, in renal aging using laser microdissection, quantitative reverse‐transcription polymerase chain reaction, and immunohistochemical analyses. In the kidneys of old SAM mice (10 months of age), a model of accelerated senescence, vitamin C, especially in the oxidized form (dehydroascorbic acid [DHA]) improves renal histology and function. Serum creatinine levels and microalbuminuria also decrease after treatment with a decline in azotemia. In addition, sodium‐vitamin C cotransporter isoform 1 levels, which were increased during aging, are normalized. In contrast, the pattern of glucose transporter 1 expression is not affected by aging or vitamin C treatment. We conclude that oxidized and reduced vitamin C are potent antiaging therapies and that DHA reverses the kidney damage observed in senescence‐accelerated prone mouse 8 to a greater degree.

中文翻译：

脱氢抗坏血酸（维生素C的氧化形式）改善了老年小鼠的肾脏组织学和功能。

氧化应激和炎症是随年龄增长的关键因素。在多种与年龄有关的疾病的进展中，抗氧化剂和生物活性化合物已被认为是有用的抗衰老剂。氧化或还原的维生素C对组织发挥不同的作用，并具有不同的新陈代谢和摄取。在这项研究中，我们使用激光显微切割，定量逆转录聚合酶链反应和免疫组化分析方法分析了维生素C（无论是氧化形式还是还原形式）在肾脏衰老中的抗衰老作用。在老年SAM小鼠（10个月大）的肾脏中，加速衰老的模型包括维生素C，尤其是氧化形式的维生素C（脱氢抗坏血酸[DHA]）改善了肾脏的组织学和功能。治疗后，血浆肌酐水平和微量白蛋白尿也降低，氮质血症减少。此外，将衰老过程中增加的维生素C共转运蛋白亚钠1水平标准化。相反，葡萄糖转运蛋白1的表达模式不受老化或维生素C处理的影响。我们得出结论，氧化和还原的维生素C是有效的抗衰老疗法，DHA在更大程度上逆转了衰老加速俯卧鼠8中观察到的肾脏损害。

更新日期：2020-05-21

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