Brain Tissue Volumes at Term‐Equivalent Age Are Associated with Early Motor Behavior in Very Preterm Infants,International Journal of Developmental Neuroscience

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Brain Tissue Volumes at Term‐Equivalent Age Are Associated with Early Motor Behavior in Very Preterm Infants
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-06-13 , DOI: 10.1002/jdn.10039
Ana Katušić ₁ , Marina Raguž ₂ , Iris Žunić Išasegi ₁

Affiliation

Preterm birth is associated with a wide range of adverse developmental outcomes, including sensory, motor, cognitive and language impairments, and behavioral or attention problems. Subtle motor deficits that might emerge in premature infants with no evident or with mild brain injury encompass qualitative and quantitative aspects of motor behavior. This prospective cohort study provided evaluation of the relationship between brain tissue volumes revealed by magnetic resonance imaging (MRI) at term-equivalent age (TEA) and motor behavior in infancy in very preterm infants (total number=40; mean gestational age=28weeks+4days; mean birthweight=1190g) without evident or with mild brain injury. Infants were recruited at birth and assessed at 12 months corrected age (CA) using the tool for qualitative and quantitative assessment of motor behavior, Infant Motor Profile (IMP). The brain tissue was segmented first using advanced segmentation techniques and the volumes were measured by summing the volumes of all voxels belonging to a particular tissue class. The associations between volumetric brain MRI measures with motor behavior were explored using linear regression analyses. Results showed that larger total brain volumes were associated with higher motor score. Similar relationships were documented for parietal lobe, deep gray matter (GM) and cerebellum volumes. Volumetric quantitative data of brain structures may serve as biomarkers for subtle motor deficits described in very preterm born infants without or with mild brain lesions apparent on MRI.

中文翻译：

足月当量年龄的脑组织体积与极早产儿的早期运动行为相关

早产与多种不良发育结果相关，包括感觉、运动、认知和语言障碍以及行为或注意力问题。没有明显脑损伤或轻度脑损伤的早产儿可能会出现微妙的运动缺陷，包括运动行为的定性和定量方面。这项前瞻性队列研究评估了极早产儿（总数=40；平均胎龄=28周+）足月当量年龄（TEA）时磁共振成像（MRI）显示的脑组织体积与婴儿期运动行为之间的关系4 天；平均出生体重 = 1190 克），无明显或轻度脑损伤。婴儿在出生时被招募，并在 12 个月校正年龄 (CA) 时使用运动行为定性和定量评估工具婴儿运动概况 (IMP) 进行评估。首先使用先进的分割技术对脑组织进行分割，并通过将属于特定组织类别的所有体素的体积相加来测量体积。使用线性回归分析探讨了体积脑部 MRI 测量与运动行为之间的关联。结果表明，较大的大脑总体积与较高的运动评分相关。顶叶、深部灰质（GM）和小脑体积也有类似的关系。大脑结构的体积定量数据可以作为在 MRI 上没有或有轻微脑损伤的极早产婴儿中描述的细微运动缺陷的生物标志物。

更新日期：2020-06-13

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