Scallop mantle toxin induces apoptosis in liver tissues of mice.,Food Science & Nutrition

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Scallop mantle toxin induces apoptosis in liver tissues of mice.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-05-20 , DOI: 10.1002/fsn3.1608
Takahide Kariya ₁ , Yasushi Hasegawa ₁

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We had previously shown that the intake of scallop mantle tissue resulted in the death of mice and rats. In this study, we investigated the liver injury caused by mantle tissue to clarify the mechanism behind its toxicity. Mantle toxin increased lipid peroxidation and decreased the reductive thiol content as well as the DPPH radical scavenging activity, catalase activity, and glutathione content in the liver of the mice. These results suggested that the mantle tissue diet caused oxidative stress through the decrease in antioxidants. In addition, mantle toxin increased the mRNA expression of endoplasmic reticulum (ER) stress‐ and inflammation‐induced genes and the protein expression of caspase‐3 and Bax (which induce apoptosis), suggesting that the mantle tissue diet causes apoptosis through oxidative stress, ER stress, and inflammation in the liver tissue. Such liver injury may be an essential cause of the rodent demise.

中文翻译：

扇贝套毒素诱导小鼠肝组织细胞凋亡。

我们之前已经证明，摄入扇贝外套膜组织会导致小鼠和大鼠死亡。在这项研究中，我们研究了外套组织引起的肝损伤，以阐明其毒性背后的机制。地幔毒素增加了小鼠肝脏中的脂质过氧化，降低了还原性硫醇含量以及DPPH自由基清除活性、过氧化氢酶活性和谷胱甘肽含量。这些结果表明，外套膜组织饮食通过抗氧化剂的减少引起氧化应激。此外，外套膜毒素增加了内质网（ER）应激和炎症诱导基因的 mRNA 表达以及 caspase-3 和 Bax（诱导细胞凋亡）的蛋白表达，表明外套膜组织饮食通过氧化应激导致细胞凋亡，内质网应激和肝组织炎症。这种肝损伤可能是啮齿动物死亡的重要原因。

更新日期：2020-05-20

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