Metabolic fate of newly developed nondigestible oligosaccharide, maltobionic acid, in rats and humans.,Food Science & Nutrition

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Metabolic fate of newly developed nondigestible oligosaccharide, maltobionic acid, in rats and humans.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-05-20 , DOI: 10.1002/fsn3.1643
Kenichi Tanabe _{1,

2} , Asuka Okuda ₂ , Fukami Ken ₃ , Natsumi Yamanaka ₂ , Sadako Nakamura ₄ , Tsuneyuki Oku ₄

Affiliation

Maltobionic acid (MA), formed by a gluconic acid and glucose linked by an α‐1,4 bond, may have the properties of a nondigestible oligosaccharide. The objective of this study was to elucidate the bioavailability of MA in rats and humans by observing digestion of MA by small intestinal enzymes, the fermentation of MA by gut microbiota, and the effect of adaptation following prolonged ingestion of MA. MA digestion was assessed using brush border membrane vesicles (BBMV) from rat small intestine. A within‐subject repeated measures design was used for ingestion experiments in 10 healthy female participants. After MA ingestion, postprandial plasma glucose and insulin levels, breath hydrogen excretion, and urinary MA were measured. The effect of adaptation following prolonged MA ingestion was investigated in rats. MA was minimally hydrolyzed by BBMV. Ingestion of 10 g of MA by healthy females did not elevate postprandial plasma glucose and insulin levels. Breath hydrogen and urinary MA were negligibly excreted over 8 hr following ingestion. Adaptation to prolonged MA ingestion produced no significant difference in exhaled hydrogen levels over 8 hr following administration compared with controls. MA is a new food material that is highly resistant to digestion and fermentation. It expresses the characteristics of a nondigestible oligosaccharide, including being low energy, improving the flavor of food and juice, and mineral solubilization.

中文翻译：

新开发的不可消化低聚糖、麦芽糖酸在大鼠和人类中的代谢命运。

麦芽糖酸 (MA) 由葡萄糖酸和葡萄糖通过 α-1,4 键连接而成，可能具有不可消化的低聚糖的特性。本研究的目的是通过观察小肠酶对 MA 的消化、肠道微生物群对 MA 的发酵以及长期摄入 MA 后的适应效果，阐明 MA 在大鼠和人类中的生物利用度。使用来自大鼠小肠的刷状缘膜囊泡 (BBMV) 评估 MA 消化。采用受试者内重复测量设计对 10 名健康女性参与者进行摄入实验。 MA摄入后，测量餐后血糖和胰岛素水平、呼气氢排泄量和尿MA。研究了大鼠长期摄入 MA 后的适应效果。 MA 被 BBMV 最小程度地水解。健康女性摄入 10 克 MA 不会升高餐后血糖和胰岛素水平。摄入后 8 小时内，呼吸氢气和尿液 MA 的排出量可以忽略不计。与对照组相比，对延长 MA 摄入的适应在给药后 8 小时内呼出的氢气水平没有产生显着差异。 MA是一种具有高度抗消化和发酵能力的新型食品原料。它体现了不易消化的低聚糖的特性，包括低能量、改善食品和果汁的风味以及溶解矿物质。

更新日期：2020-05-20

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