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Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-05-20 , DOI: 10.1002/fsn3.1640 Md Mizanur Rahman 1 , Khandoker Usran Ferdous 1 , Shraboni Roy 1 , Iffat Ara Nitul 1 , Fariha Mamun 1 , Md Hemayet Hossain 2 , Nusrat Subhan 1 , Md Ashraful Alam 1 , Md Areeful Haque 3, 4
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-05-20 , DOI: 10.1002/fsn3.1640 Md Mizanur Rahman 1 , Khandoker Usran Ferdous 1 , Shraboni Roy 1 , Iffat Ara Nitul 1 , Fariha Mamun 1 , Md Hemayet Hossain 2 , Nusrat Subhan 1 , Md Ashraful Alam 1 , Md Areeful Haque 3, 4
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Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial.
中文翻译：
余甘子的多酚化合物可预防 2K1C 大鼠肾脏和心脏的氧化应激和纤维化。
余甘子（余甘子）是抗氧化剂的天然来源，具有宝贵的药用特性。然而，余甘子对双肾一夹（2K1C）大鼠肾脏的保护作用尚未得到充分解释。本研究旨在评估补充余甘子果粉（2.5% W/W）对 2K1C 大鼠肾脏的肾脏保护作用。与对照组相比，2K1C 大鼠的残余肾湿重增加，血浆肌酐和尿酸浓度也增加。补充余甘子可改善 2K1C 大鼠血浆中肌酐和尿酸浓度升高的情况。 2K1C 大鼠血浆、心脏和肾脏组织中的各种氧化应激指标，如丙二醛、一氧化氮 (NO) 和高级蛋白质氧化产物 (APOP) 也有所增加，而补充醋栗也将这些指标显着降至正常水平。此外，补充余甘子可防止 2K1C 大鼠组织中的炎症细胞进入和纤维化。这些研究结果表明，余甘子可以恢复 2K1C 大鼠的血浆抗氧化能力，并预防氧化应激、炎症和纤维化。以这些结果为基础，临床上在饮食或果汁中补充干余甘子粉对慢性肾病患者将是有益的。
更新日期：2020-05-20
中文翻译：
余甘子的多酚化合物可预防 2K1C 大鼠肾脏和心脏的氧化应激和纤维化。
余甘子（余甘子）是抗氧化剂的天然来源，具有宝贵的药用特性。然而，余甘子对双肾一夹（2K1C）大鼠肾脏的保护作用尚未得到充分解释。本研究旨在评估补充余甘子果粉（2.5% W/W）对 2K1C 大鼠肾脏的肾脏保护作用。与对照组相比，2K1C 大鼠的残余肾湿重增加，血浆肌酐和尿酸浓度也增加。补充余甘子可改善 2K1C 大鼠血浆中肌酐和尿酸浓度升高的情况。 2K1C 大鼠血浆、心脏和肾脏组织中的各种氧化应激指标，如丙二醛、一氧化氮 (NO) 和高级蛋白质氧化产物 (APOP) 也有所增加，而补充醋栗也将这些指标显着降至正常水平。此外，补充余甘子可防止 2K1C 大鼠组织中的炎症细胞进入和纤维化。这些研究结果表明，余甘子可以恢复 2K1C 大鼠的血浆抗氧化能力，并预防氧化应激、炎症和纤维化。以这些结果为基础，临床上在饮食或果汁中补充干余甘子粉对慢性肾病患者将是有益的。
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