Cytomegalovirus (CMV) infection elicits a potent immune response that includes the stimulation of antibodies with neutralizing activity. Recent studies have focused on elucidating the role of neutralizing antibodies in protecting against CMV infection and disease and characterizing viral antigens against which neutralizing antibodies are directed. Here, we provide a synthesis of recent data regarding the role of neutralizing antibodies in protection against CMV infection/disease. We consider the role of humoral immunity in the context of the global CMV-specific immune response, and the implications that recent findings have for vaccine and antibody-based therapy design.

巨细胞病毒（CMV）感染引起有效的免疫反应，其中包括刺激具有中和活性的抗体。最近的研究集中在阐明中和抗体在防止CMV感染和疾病中的作用以及表征中和抗体所针对的病毒抗原。在这里，我们提供了有关中和抗体对CMV感染/疾病的保护作用的最新数据的综述。我们考虑了体液免疫在全球CMV特异性免疫反应中的作用，以及最近发现对疫苗和基于抗体的治疗设计的影响。