Recently, we demonstrated an integrated photoacoustic (PA) and ultrasound (PAUS) system using a kHz-rate wavelength-tunable laser and a swept-beam delivery approach. It irradiates a medium using a narrow laser beam swept at high repetition rate (∼1 kHz) over the desired imaging area, in contrast to the conventional PA approach using broad-beam illumination at a low repetition rate (10−50 Hz). Here, we present a method to correct the wavelength-dependent fluence distribution and demonstrate its performance in phantom studies using a conventional limited view/bandwidth hand-held US probe. We adopted analytic fluence models, extending diffusion theory for the case of a pencil beam obliquely incident on an optically homogenous turbid medium, and developed a robust method to estimate fluence attenuation in the medium using PA measurements acquired from multiple fiber-irradiation positions swept at a kHz rate. We conducted comprehensive simulation tests and phantom studies using well-known contrast-agents to validate the reliability of the fluence model and its spectral corrections.

最近，我们展示了一种使用 kHz 速率波长可调谐激光器和扫频光束传输方法的集成光声 (PA) 和超声 (PAUS) 系统。它使用窄激光束以高重复率 (∼1 kHz) 扫过所需的成像区域来照射介质，这与使用低重复率 (10−50 Hz) 宽光束照明的传统 PA 方法形成鲜明对比。在这里，我们提出了一种校正波长相关注量分布的方法，并使用传统的有限视图/带宽手持式超声探头在体模研究中展示其性能。我们采用了解析注量模型，将扩散理论扩展到了笔形光束倾斜入射到光学均匀混浊介质上的情况，并开发了一种稳健的方法，使用从以一定频率扫描的多个光纤照射位置获取的 PA 测量来估计介质中的注量衰减。千赫率。我们使用众所周知的造影剂进行了全面的模拟测试和模型研究，以验证注量模型及其光谱校正的可靠性。