Schizophrenia patients are at higher risk of engaging in violent behavior than the general population. Schizophrenia is also regarded as a highly heritable disorder. This study aims to analyze genome-wide the effect of SNPs on violence in schizophrenia. We recruited 205 subjects between the age of 18-75 from the Centre for Addiction and Mental Health (CAMH), who had a diagnosis of schizophrenia or schizoaffective disorder. We recorded physical, verbal and lifetime violence scores indicating any violent actions to inflict pain, bodily harm, or death on another individual from the standardized scale, Modified Overt Aggression Scale (MOAS). We genotyped each participant DNA using the Illumina Omni 2.5, and the SNPs were analyzed using the whole genome analysis tool-set, PLINK. We probed for single nucleotide polymorphisms (SNPs) correlated with violence in schizophrenia patients. We found one SNP (rs2188177) on chromosome 7 which showed a trend for association with physical violence (p = 7.80E-06). This study is the first of its kind to investigate genome-wide, the polymorphisms associated with violence in schizophrenia. The findings of this study may promote collaborative efforts to understand the genetic basis of violent behavior in psychosis.

中文翻译：

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精神分裂症的侵略和暴力的全基因组关联研究。

精神分裂症患者发生暴力行为的风险高于一般人群。精神分裂症也被认为是高度遗传的疾病。这项研究旨在分析全基因组SNP对精神分裂症中暴力的影响。我们从成瘾与心理健康中心（CAMH）招募了205位年龄在18-75岁之间的受试者，他们被诊断为精神分裂症或精神分裂症。我们记录了身体，言语和一生的暴力得分，这些得分表明从标准化量表（改良的公开攻击量表，MOAS）中对另一人造成的痛苦，身体伤害或死亡的任何暴力行为。我们使用Illumina Omni 2.5对每个参与者的DNA进行基因分型，并使用整个基因组分析工具集PLINK对SNP进行了分析。我们探讨了与精神分裂症患者暴力相关的单核苷酸多态性（SNP）。我们在7号染色体上发现了一个SNP（rs2188177），该SNP显示出与身体暴力相关的趋势（p = 7.80E-06）。这项研究是首次进行全基因组研究，即与精神分裂症中的暴力相关的多态性。这项研究的结果可能会促进人们共同努力，以了解精神病患者暴力行为的遗传基础。