An increasing number of neuroimaging studies addressing patients with corticobasal syndrome use macroscopic definitions of brain regions. As a closer link to functionally relevant units, we aimed at identifying magnetic resonance-based atrophy patterns in regions defined by probability maps of cortical microstructure. For this purpose, three analyses were conducted: (1) Whole-brain cortical thickness was compared between 36 patients with corticobasal syndrome and 24 controls. A pattern of pericentral atrophy was found, covering primary motor area 4, premotor area 6, and primary somatosensory areas 1, 2, and 3a. Within the central region, only area 3b was without atrophy. (2) In 18 patients, longitudinal measures with follow-ups of up to 59 months (mean 21.3 ± 15.4) were analyzed. Areas 1, 2, and 6 showed significantly faster atrophy rates than primary somatosensory area 3b. (3) In an individual autopsy case, longitudinal in vivo morphometry and postmortem pathohistology were conducted. The rate of magnetic resonance-based atrophy was significantly correlated with tufted-astrocyte load in those cytoarchitectonically defined regions also seen in the group study, with area 3b being selectively unaffected.

中文翻译：

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体感区 3b 在皮质基底膜综合征中选择性不受影响：结合 MRI 和组织学

越来越多的针对皮质基底细胞综合征患者的神经影像学研究使用大脑区域的宏观定义。作为与功能相关单位的更紧密联系，我们旨在识别由皮质微结构概率图定义的区域中基于磁共振的萎缩模式。为此，进行了三项分析：（1）比较了 36 名皮质基底综合征患者和 24 名对照者的全脑皮质厚度。发现中央周围萎缩模式，覆盖初级运动区 4、运动前区 6 和初级体感区 1、2 和 3a。在中部地区，只有3b区没有萎缩。(2) 在 18 名患者中，对长达 59 个月（平均 21.3 ± 15.4）的随访进行了纵向测量。区域 1, 2, 和 6 的萎缩速度明显快于初级体感区 3b。(3) 在个体尸检案例中，进行了纵向活体形态测量和死后病理组织学检查。在小组研究中也看到的那些细胞结构定义的区域中，基于磁共振的萎缩率与簇状星形胶质细胞负载显着相关，区域 3b 选择性不受影响。