Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.

心肌梗塞 (MI) 后心脏伤口愈合从促炎发展到抗炎再到修复反应，心脏成纤维细胞是整个转变过程中的核心参与者。成纤维细胞通过经历促炎、抗炎和促瘢痕产生特征的连续极化表型来反映左心室梗塞中所见的变化。每个表型转变的发展取决于成纤维细胞进入的 MI 环境。在这篇小型综述中，我们总结了我们目前关于 MI 期间心脏成纤维细胞活化的知识，并强调了仍然存在差距的关键领域。