Implant-associated infections present severe and difficult-to-treat complications after surgery, related to implant biofilm colonization. Systemic administration of antibiotics cannot reach sufficient concentrations at the infected site and may be toxic. Here we describe how mussel-inspired dendritic material coated on a titanium surface can locally activate a prodrug of daptomycin (pro-dapto) to treat methicillin-resistant Staphylococcus aureus. The mechanism of the prodrug activation is based on bio-orthogonal click chemistry between a tetrazine (Tz) and trans-cyclooctene (TCO). The former is attached to the dendritic polymer, while the later converts daptomycin into a prodrug. Characterization of the material's properties revealed that it is hydrophobic, non-toxic, and stable for a prolonged period of time. We envision that the titanium coated dendritic material will be able to improve the treatment of implant-associated infections by concentrating systemically administered antibiotic prodrugs, thus converting them into active localized medicines.

植入物相关的感染在手术后呈现出严重且难以治疗的并发症，与植入物生物膜定植有关。在感染部位全身性应用抗生素不能达到足够的浓度，并且可能是有毒的。在这里，我们描述了涂在钛表面上的贻贝启发性树突状材料如何局部激活达托霉素的前药（pro-dapto）来治疗耐甲氧西林的金黄色葡萄球菌。前药激活的机制基于四嗪（Tz）与反式之间的生物正交点击化学-环辛烯（TCO）。前者附着在树状聚合物上，而后者将达托霉素转化为前药。材料特性的表征表明，它是疏水的，无毒的，并且可以长时间稳定。我们预见，通过浓缩全身施用的抗生素前药，从而将它们转变成活性的局部药物，钛涂层的树突状材料将能够改善植入物相关感染的治疗。