Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells and regulatory T cells. Identification of the underlying mechanism of such aberrant function of immune system would help in the prediction of disease course and selection of susceptible patients for more intensive cares. In the current review, we summarize the results of studies which reported alterations in cytokine levels and immune cell functions in patients affected with SARS-CoV-2 and related viruses.

中文翻译：

---

SARS-CoV-2 感染及相关病症患者的细胞因子水平和免疫反应发生改变


摘要 严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 于 2020 年初引起全球大流行。这种感染与多种临床症状有关。在严重受影响的患者中，它导致免疫反应失调，包括炎症细胞因子过度分泌以及幼稚辅助 T 细胞、记忆辅助 T 细胞和调节性 T 细胞比例失衡。识别免疫系统这种异常功能的潜在机制将有助于预测病程并选择易感患者进行更重症监护。在当前的综述中，我们总结了一些研究结果，这些研究报告了感染 SARS-CoV-2 和相关病毒的患者细胞因子水平和免疫细胞功能的变化。