Introduction Strontium-82/Rubidium-82 ( 82 Sr/ 82 Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82 Rb isotope yield and production efficiency of two FDA-approved 82 Sr/ 82 Rb generators were compared. Methods N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82 ® and 9 RUBY-FILL ® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL ® system to determine an empirical correction-factor used to convert CardioGen-82 ® daily QA values of 82 Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min −1 ) to RUBY-FILL ® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min −1 ). The generator yield ( 82 Rb) and production efficiency ( 82 Rb yield/ 82 Sr parent activity) were measured and compared after this conversion to a common scale. Results At the start of clinical use, the system reported 82 Rb activity from daily QA was lower for CardioGen-82 ® vs RUBY-FILL ® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82 Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82 ® ) values were found to under-estimate the integrated ‘total’ (RUBY-FILL ® ) activity by ~ 24% at 50 mL·min −1 . When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82 ® efficiency remained slightly lower than the RUBY-FILL ® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82 Rb production improved for both systems over the respective periods of clinical use. Conclusions 82 Rb generator yield was significantly under-estimated using the CardioGen-82 ® vs RUBY-FILL ® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82 Rb production efficiency of the CardioGen-82 ® system was ~ 7% lower than RUBY-FILL ® over the full period of clinical use.

中文翻译：

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用于 PET 灌注成像的铷 82 发生器产量和效率：两种临床系统的比较


简介 锶 82/铷 82 ( 82 Sr/ 82 Rb) 发生器广泛用于心肌灌注的正电子发射断层扫描 (PET) 成像。在本研究中，比较了两种 FDA 批准的 82 Sr/ 82 Rb 发生器的 82 Rb 同位素产量和生产效率。方法 对来自 9 个 CardioGen-82 ® 和 9 个 RUBY-FILL ® 发生器的 N = 515 份连续每日质量保证 (QA) 报告进行了为期 2 年的审查。在 RUBY-FILL® 系统上以不同流速进行了一系列测试洗脱，以确定用于转换 CardioGen-82® 82 Rb 活性每日 QA 值的经验校正因子（剂量校准器“最大”为 50 mL） 50 mL·min -1 的洗脱）至 RUBY-FILL ® 等效值（20 mL·min -1 的 35 mL 洗脱的积分“总计”）。在转换为通用规模后，测量并比较了发电机产量（ 82 Rb）和生产效率（ 82 Rb 产量/ 82 Sr 母体活性）。结果 在临床使用开始时，系统报告每日 QA 的 82 Rb 活性较低，CardioGen-82 ® 与 RUBY-FILL ® 相比（2.3 ± 0.2 vs 3.0 ± 0.2 GBq，P < 0.001），尽管 82 Sr 活性相似。发现剂量校准器“最大”(CardioGen-82 ® ) 值在 50 mL·min -1 时低估了积分“总”(RUBY-FILL ® ) 活性约 24%。当使用这些数据将 CardioGen-82 值转换为通用测量尺度（综合总活性）时，CardioGen-82 ® 效率平均仍略低于 RUBY-FILL ® 系统（88 ± 4% vs 95 ± 4%） ，P < 0.001）。在各自的临床使用期间，两个系统的 82 Rb 生产效率均有所提高。结论 使用 CardioGen-82 ® 与 RUBY-FILL ® 每日 QA 程序相比，82 Rb 发生器的产量明显被低估。 当发生器产量表示为两个系统的综合总活性时，在整个临床使用期间，CardioGen-82 ® 系统的估计 82 Rb 生产效率比 RUBY-FILL ® 低约 7%。