PURPOSE Patients with familial adenomatous polyposis (FAP) may undergo either ileorectal anastomosis (IRA) or ileal pouch anal anastomosis (IPAA) depending on the degree of rectal involvement. Desmoid tumors (DTs) may arise postoperatively. Whether IPAA is associated with a higher risk of DTs as compared with IRA remains controversial. The purpose of this study was to determine whether IPAA increased the risk of DTs by analyzing the published data that compared IRA and IPAA as the primary treatment for FAP. METHODS A metaanalysis was performed to analyze the published data between 1989 and 2019. IRA and IPAA were compared with respect to the incidence of DTs. RESULTS Eight retrospective studies with a total of 1072 patients were identified: 491 underwent IPAA and 581 IRA. There was no significant difference in the incidence of DTs between IPAA and IRA (11.81% vs. 9.47%, OR 0.95, P = 0.85). Meanwhile, the overall complication (42.97% vs. 36.76%, OR 1.32, P = 0.11), incidence of cancer (4.88% vs. 8.37%, OR 0.28, P = 0.26), and overall mortality (0.33% vs. 5.20%, OR 0.49, P = 0.53) were comparable too. CONCLUSION Ileoanal pouch surgery is associated with similar risk of desmoid in patients with FAP after surgery.

中文翻译：

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回肠袋手术是否会增加家族性腺瘤性息肉病患者类胶质瘤的风险？

目的家族性腺瘤性息肉病（FAP）患者可根据直肠受累程度接受回肠直肠吻合术（IRA）或回肠囊肛门吻合术（IPAA）。胶质瘤（DTs）可能会在术后出现。与IRA相比，IPAA是否与较高的DT风险相关仍存在争议。这项研究的目的是通过分析比较IRA和IPAA作为FAP的主要治疗方法的已发表数据来确定IPAA是否增加了DT的风险。方法采用荟萃分析法分析了1989年至2019年间发表的数据。比较了IRA和IPAA的DT发生率。结果确定了八项回顾性研究，共1072例患者：491例接受了IPAA和581例IRA。IPAA和IRA之间的DT发生率无显着差异（11.81％vs. 9.47％，或0.95，P = 0.85）。同时，总体并发症（42.97％vs. 36.76％，OR 1.32，P = 0.11），癌症发生率（4.88％vs. 8.37％，OR 0.28，P = 0.26）和总死亡率（0.33％vs.5.20％） ，或0.49，P = 0.53）也具有可比性。结论肛肠袋手术与FAP患者术后类皮瘤的风险相似。