Family history of melanoma is a major melanoma risk factor. However, self-reported family histories for some cancers, including melanoma, are commonly inaccurate. We used a unique database, the Utah Population Database (UPDB), as well as the Utah Cancer Registry to determine the accuracy of self-reported family history of melanoma in a large cohort of high-risk patients. Patient charts were reviewed and compared to records in the UPDB and the UCR to confirm personal and family history of melanoma in 1780 patients enrolled in a total body photography monitoring program. Self-reported family history of melanoma in first-degree relatives had an overall sensitivity of 71%, specificity of 79%, PPV of 31%, and NPV of 95%, with decreased accuracy (PPV) for second-degree relatives. A personal history of melanoma was the only factor significantly associated with accuracy in self-reported family history of melanoma. Patient age, sex, estimated nevus count, and number of prior personal melanomas were not significant predictors. Dermatologists should educate patients on the differences between melanomas, keratinocyte carcinomas, and pre-cancers. Confirming self-reported family history of melanoma may improve risk assessment for patients undergoing screening.

中文翻译：

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高危患者自我报告黑色素瘤家族史的准确性较低。

黑色素瘤家族史是主要的黑色素瘤危险因素。然而，自我报告的某些癌症（包括黑色素瘤）的家族史通常是不准确的。我们使用了一个独特的数据库，即犹他州人口数据库 (UPDB) 以及犹他州癌症登记处，以确定在一大群高危患者中自我报告的黑色素瘤家族史的准确性。患者图表经过审查并与 UPDB 和 UCR 中的记录进行比较，以确认参加全身摄影监测计划的 1780 名患者的个人和家族黑色素瘤病史。一级亲属中自我报告的黑色素瘤家族史的总体敏感性为 71%，特异性为 79%，PPV 为 31%，NPV 为 95%，二级亲属的准确性 (PPV) 降低。黑色素瘤的个人病史是与自我报告的黑色素瘤家族史的准确性显着相关的唯一因素。患者的年龄、性别、估计的痣数量和既往个人黑色素瘤的数量不是重要的预测因素。皮肤科医生应教育患者黑色素瘤、角质形成细胞癌和癌前病变之间的差异。确认自我报告的黑色素瘤家族史可能会改善接受筛查的患者的风险评估。