Purpose of Review

Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are the second most common cutaneous lymphomas after mycosis fungoides and Sezary syndrome. They include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. The purpose of this literature review is to consolidate the available evidence on the primary cutaneous CD30+ LPD in order to define the tools for correct diagnosis and appropriate treatment.

Recent Findings

The current body of knowledge regarding the clinical features, histopathologic changes, recently described genetic alterations, and therapeutic options will be covered in this comprehensive review.

Summary

Primary cutaneous CD30+ LPD represent rare cutaneous lymphomas that have significant histologic overlap within the defined group as well as with other neoplastic and reactive entities. The importance of differentiating these entities is crucial, as each one has a different clinical course and prognosis.

中文翻译：

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原发性皮肤CD30 +淋巴增生性疾病：全面综述。

审查目的

原发性皮肤CD30 + T细胞淋巴组织增生性疾病（CD30 + LPD）是继真菌病真菌和Sezary综合征之后的第二大常见皮肤淋巴瘤。它们包括原发性皮肤间变性大细胞淋巴瘤（pcALCL），淋巴瘤样丘疹（LyP）和交界性病变。这篇文献综述的目的是巩固有关原发性皮肤CD30 + LPD的现有证据，以便定义正确诊断和适当治疗的工具。

最近的发现

关于临床特征，组织病理学变化，最近描述的遗传改变和治疗选择的当前知识将在本综合综述中涵盖。

概要

原发性皮肤CD30 + LPD代表罕见的皮肤淋巴瘤，在定义的组以及其他肿瘤和反应性实体中具有明显的组织学重叠。区分这些实体的重要性至关重要，因为每个实体都有不同的临床过程和预后。