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Result of awake surgery for pediatric eloquent brain area tumors: single-center experience.
Child's Nervous System ( IF 1.3 ) Pub Date : 2020-05-21 , DOI: 10.1007/s00381-020-04666-8
Mikle Talabaev 1 , Kevin Venegas 1 , Gleb Zabrodets 2 , Volha Zmachinskaya 2 , Alexander Antonenko 3 , Dmitry Naumenko 3 , Hanna Salauyeva 1 , Natalia Churyla 4
Affiliation  

PURPOSE About half of brain tumors are located in supratentorial regions and 20% of them in eloquent brain cortex areas. The use of fMRI and intraoperative neuromonitoring allows safe surgery of these areas. Carrying out awake brain surgery (ABS) operations provides additional opportunities for direct-function monitoring. In pediatric practice, this method has not been used widely yet. METHODS We present the retrospective analysis of the results of pre-operative examination and surgical treatment of 12 patients with glial tumors located in eloquent cortex areas. Two patients had ABS operations twice. Intraoperative neuromonitoring was used in all the cases. RESULTS Twelve patients in total underwent fourteen ABS operations. According to histology results, patients with low-grade tumors prevailed, 11 (91.7%) out of 12. Seven (58.3%) patients had the tumor located in the projection of speech cortex area, four (33.3%) patients in the motor cortex area, and one (8.4%) patient in the visual cortex area. The youngest male was 8 years old. Temporary neurological deficit was diagnosed in three (25%) cases. The tumor was removed completely in 66.7% (eight) cases. Three patients were operated upon twice, two of whom had ABS operations twice. The awake phase of the surgery lasted from 30 to 110 min, 61.2 min on average. CONCLUSIONS Our experience has shown sufficient safety of pediatric ABS operations. The achieved functional result and radicality of tumor removal prove that further application and development of this method for children with eloquent brain area tumors (EBATs) is reasonable.

中文翻译:

小儿雄辩性脑区肿瘤清醒手术的结果:单中心经验。

目的大约一半的脑肿瘤位于上皮区,其中20%位于雄辩的大脑皮层区。使用fMRI和术中神经监测可以对这些区域进行安全手术。进行清醒脑外科手术(ABS)可以提供直接功能监视的其他机会。在儿科实践中,该方法尚未广泛使用。方法我们回顾性分析了位于皮质区的12例神经胶质瘤患者的术前检查和手术治疗的结果。2例患者进行了两次ABS手术。所有病例均采用术中神经监测。结果总共有12名患者接受了14次ABS手术。根据组织学结果,低度肿瘤患者占12位中的11位(91.7%),占七位。58位。3%的患者肿瘤位于言语皮质区域的投影中,四名(33.3%)患者位于运动皮层区域,而一名(8.4%)患者位于视觉皮层区域。最小的男性是8岁。三例(25%)病例被诊断为暂时性神经功能缺损。66.7%(八)例肿瘤被完全清除。三名患者接受了两次手术,其中两名接受了ABS手术两次。手术的清醒阶段持续30到110分钟,平均61.2分钟。结论我们的经验表明,小儿ABS手术具有足够的安全性。取得的功能性结果和彻底的肿瘤切除证明了该方法在雄辩性脑区域肿瘤(EBAT)儿童中的进一步应用和发展是合理的。运动皮层区域的患者为3%,视觉皮层区域的患者为(8.4%)。最小的男性是8岁。三例(25%)病例被诊断为暂时性神经功能缺损。66.7%(八)例肿瘤被完全清除。三名患者接受了两次手术,其中两名接受了ABS手术两次。手术的清醒阶段持续30到110分钟,平均61.2分钟。结论我们的经验表明,小儿ABS手术具有足够的安全性。取得的功能性结果和彻底的肿瘤切除证明了该方法在雄辩性脑区域肿瘤(EBAT)儿童中的进一步应用和发展是合理的。运动皮层区域的患者为3%,视觉皮层区域的患者为(8.4%)。最小的男性是8岁。三例(25%)病例被诊断为暂时性神经功能缺损。66.7%(八)例肿瘤被完全清除。三名患者接受了两次手术,其中两名接受了ABS手术两次。手术的清醒阶段持续30到110分钟,平均61.2分钟。结论我们的经验表明,小儿ABS手术具有足够的安全性。取得的功能性结果和彻底的肿瘤切除证明了该方法在雄辩性脑区域肿瘤(EBAT)儿童中的进一步应用和发展是合理的。66.7%(八)例肿瘤被完全清除。三名患者接受了两次手术,其中两名接受了ABS手术两次。手术的清醒阶段持续30到110分钟,平均61.2分钟。结论我们的经验表明,小儿ABS手术具有足够的安全性。取得的功能性结果和彻底的肿瘤切除术证明,该方法在雄辩性脑区域肿瘤(EBAT)儿童中的进一步应用和开发是合理的。66.7%(八)例肿瘤被完全清除。三名患者接受了两次手术,其中两名接受了ABS手术两次。手术的清醒阶段持续30到110分钟,平均61.2分钟。结论我们的经验表明,小儿ABS手术具有足够的安全性。取得的功能性结果和彻底的肿瘤切除术证明,该方法在雄辩性脑区域肿瘤(EBAT)儿童中的进一步应用和开发是合理的。
更新日期:2020-05-21
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