Experimental studies of the escape events of single-stranded DNA (ssDNA) molecules from the membrane embedded α -hemolysin nanopores exhibited the non-exponential kinetics. The data for homopolymers of adenine (dA27) and cytosine (dC27) revealed the profound influence of the sequence dependent DNA–pore interactions and the applied potentials on the escape kinetics. The non-exponential behavior is a signature of the presence of disorder in biochemical reactions. Here, we rationalize the experimental results with a dynamic disorder approach based on Zwanzig’s fluctuating bottleneck (FB) model as a general mechanism where the rate of the reaction is controlled by the passage of a molecule through the cross-sectional area of the vestibule of the α -hemolysin channel (the bottleneck). The stochastic fluctuations of the radius of the latter is represented by the fluctuations of the intersegment distance of a Rouse chain, the dynamics of which is described using a non-Marko...

中文翻译：

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ssDNA分子从α-溶血素纳米孔中逃逸的动力学：动态失调研究

单链DNA（ssDNA）分子从膜包埋的α-溶血素纳米孔中逃逸事件的实验研究显示出非指数动力学。腺嘌呤（dA27）和胞嘧啶（dC27）均聚物的数据揭示了依赖序列的DNA-孔相互作用以及施加的电势对逃逸动力学的深刻影响。非指数行为是生化反应中疾病存在的标志。在这里，我们以Zwanzig波动瓶颈（FB）模型为基础的动态无序方法使实验结果合理化，该机理是反应速率受分子通过通道前庭横截面积的控制。 α-溶血素通道（瓶颈）。