BACKGROUND Black women in the United States and Africa are at an increased risk for preeclampsia. Allelic variants in the gene for apolipoprotein LI, APOL1, are found only in populations of African ancestry, and have been shown to contribute significant risk for kidney disease. Recent studies suggest these APOL1 variants also may contribute risk for preeclampsia. METHODS The association of preeclampsia with carriage of APOL1 risk alleles was evaluated in a case-control study of deliveries from black women at a single center in Cleveland, Ohio that included gross and histopathologic evaluations of placental tissues (395 cases and 282 controls). Using logistic regression models, associations between fetal APOL1 genotype and preeclampsia were evaluated using several case definitions based on prematurity and severity of preeclampsia, with uncomplicated term pregnancies as controls. Associations between APOL1 genotype and pathological features were also examined. RESULTS The infant APOL1 genotype was significantly associated with preeclampsia in a dominant inheritance pattern with odds ratio of 1.41 (P=0.029, 95% CI 1.037, 1.926). Stratifying preeclampsia cases by preterm birth, significant associations were detected for both recessive (O.R.=1.70, P=0.038) and additive (O.R.=1.33, P=0.028) inheritance patterns. APOL1 genotype, however, was not significantly associated with pathological changes or other perinatal observations. CONCLUSIONS Preeclampsia appears to be another disease associated with APOL1 variants, however, further studies are needed to increase confidence in the mode of inheritance. By understanding the association of APOL1 variants with preeclampsia, genetic screening tests for APOL1 may be useful to predict at-risk pregnancies and targeted interventions may be developed to improve pregnancy outcomes.

中文翻译：

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非裔子痫前期与婴儿APOL1基因型的关联。

背景技术在美国和非洲的黑人妇女患先兆子痫的风险增加。载脂蛋白L1基因APOL1的等位基因变体仅在非洲血统的人群中发现，并已证明对肾脏疾病具有重大风险。最近的研究表明，这些APOL1变体也可能导致先兆子痫的风险。方法在俄亥俄州克利夫兰市一个中心的黑人妇女分娩病例对照研究中评估了子痫前期与携带APOL1风险等位基因的关联，该研究包括胎盘组织的总体和组织病理学评估（395例和282例对照）。使用logistic回归模型，根据先兆子痫的早产和严重程度，使用几种病例定义评估了胎儿APOL1基因型与先兆子痫之间的关联，以简单的足月妊娠作为对照。还检查了APOL1基因型与病理特征之间的关联。结果婴儿APOL1基因型与先兆子痫显着相关，优势遗传模式，比值比为1.41（P = 0.029，95％CI 1.037，1.926）。通过早产对子痫前期病例进行分层，发现隐性（OR = 1.70，P = 0.038）和加性（OR = 1.33，P = 0.028）遗传模式之间存在显着关联。然而，APOL1基因型与病理变化或其他围产期观察结果无显着相关性。结论先兆子痫似乎是与APOL1变异有关的另一种疾病，但是，需要进一步的研究来增加对遗传模式的信心。通过了解APOL1变异体与子痫前期的关系，