BACKGROUND Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. METHODS This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin's Lymphoma, from Manaus, Brazil. RESULTS The new C. neoformans was susceptible to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil. CONCLUSIONS In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group.

中文翻译：

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从巴西亚马逊地区一名非霍奇金淋巴瘤患者中分离出新的隐球菌ST623。

背景技术隐球菌病是一种地理分布广泛的疾病。当它影响免疫力低下的患者，艾滋病，结核病或其他需要长期住院的疾病时，这是最关键的。方法该研究描述了一个病例报告，分子流行病学，系统发育关系以及对来自巴西马瑙斯市的非霍奇金淋巴瘤患者新分离出的新形成梭状芽胞杆菌ST 623的抗真菌药敏试验。结果新的新孢子虫对所有测试的抗真菌药物均敏感。我们的结果表明，ST623新克隆与在巴西鉴定出的VNI亚型组的任何其他ST没有明显的进化接近性。结论在系统发育分析的背景下，该新基因型属于VNI亚型，