The study aimed to assess the role and the relationship of adipokines as well as parameters of arterial stiffness in newly diagnosed hypertension. Forty-nine newly diagnosed hypertensive cases (median age 47 ± 6 years) and 48 normotensive patients (median age 47 ± 6 years) were enrolled to this study. Patients underwent echocardiography, noninvasive assessment of hemodynamic parameters using SphygmoCor tonometer (Atcor Med). The levels of the adipokines-leptin, adiponectin, and resistin-were investigated. The augmentation pressure, augmentation index, and pulse wave velocity (PWV) were higher in patients with hypertension compared with controls (Ps < .05). Patients with hypertension had higher E/E' ratio, higher diameter of left atrium, and lower tricuspid annular plane systolic excursion compared with the control group (Ps < .05). Patients with hypertension had significant higher levels of leptin (ng/mL) and lower levels of adiponectin (μg/mL) compared with normotensive patients. The multivariate analysis showed that PWV (odds ratio [OR] 1.95, 95% CI, 1.2-2.9; P = .002) and leptin level (OR 1.01, 95% CI, 1.004-1.031; P = .01) were significantly associated with hypertension. Arterial stiffness as determined by PWV and leptin are associated with newly diagnosed hypertension. Elevated serum leptin level may influence the potential mechanism leading to sympathetic activation.

中文翻译：

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脂肪因子在动脉僵硬和高血压发展中的作用。

这项研究旨在评估在新诊断的高血压中脂肪因子的作用和关系以及动脉僵硬度参数。本研究招募了49名新诊断的高血压病例（中位年龄47±6岁）和48名血压正常的患者（中位年龄47±6岁）。患者接受超声心动图检查，使用SphygmoCor眼压计（Atcor Med）对血流动力学参数进行无创评估。研究了脂联素-瘦素，脂联素和抵抗素的水平。与对照组相比，高血压患者的增强压力，增强指数和脉搏波速度（PWV）更高（Ps <.05）。与对照组相比，高血压患者的E / E'比更高，左心房直径更大，三尖瓣环平面收缩期偏移更低（Ps <.05）。与血压正常的患者相比，高血压患者的瘦素（ng / mL）水平明显升高，脂联素（μg/ mL）水平则明显降低。多元分析显示PWV（赔率[OR] 1.95，95％CI，1.2-2.9; P = .002）和瘦素水平（OR 1.01，95％CI，1.004-1.031; P = .01）显着相关患有高血压。由PWV和瘦素确定的动脉僵硬度与新诊断的高血压有关。血清瘦素水平升高可能影响导致交感神经激活的潜在机制。01）与高血压显着相关。由PWV和瘦素确定的动脉僵硬度与新诊断的高血压有关。血清瘦素水平升高可能影响导致交感神经激活的潜在机制。01）与高血压显着相关。由PWV和瘦素确定的动脉僵硬度与新诊断的高血压有关。血清瘦素水平升高可能影响导致交感神经激活的潜在机制。