Some animals respond to injury by inducing new growth to regenerate the lost structures. This regenerative growth must be carefully controlled and constrained to prevent overgrowth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. Using a genetic ablation system in the Drosophila wing imaginal disc, we have identified one mechanism that constrains regenerative growth, impairment of which also leads to erroneous patterning of the final appendage. Regenerating discs with reduced levels of the RNA-regulator Brain tumor (Brat) exhibit enhanced regeneration, but produce adult wings with disrupted margins that are missing extensive tracts of sensory bristles. In these mutants, aberrantly high expression of the pro-growth factor Myc and its downstream targets likely contributes to this loss of cell-fate specification. Thus, Brat constrains the expression of pro-regeneration genes and ensures that the regenerating tissue forms the proper final structure.

中文翻译：

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再生生长受到脑肿瘤的限制，以确保果蝇的正确模式

一些动物通过诱导新的生长来再生丢失的结构来应对伤害。必须仔细控制和限制这种再生生长，以防止过度生长并允许再生组织的正确组织。然而，尚未确定限制再生生长的因素。在果蝇中使用基因消融系统翼成像盘，我们已经确定了一种限制再生生长的机制，其损伤也会导致最终附属物的错误模式。RNA 调节剂脑肿瘤 (Brat) 水平降低的再生椎间盘表现出增强的再生能力，但会产生边缘受损的成年翅膀，这些翅膀缺少大量的感觉刚毛。在这些突变体中，促生长因子 Myc 及其下游靶标的异常高表达可能导致细胞命运规范的丧失。因此，Brat 限制了促再生基因的表达，并确保再生组织形成正确的最终结构。