Background: Little is known about what factors can modify the relationship between affective symptoms and cognitive function across the life course.Aim: To investigate a number of factors that can contribute to resilience in cognitive function in relation to affective symptoms, using data from the National Child Development Study.Subjects and methods: Adult affective symptoms were measured using the Malaise Inventory Scale (ages 23, 33, 42 and 50). Measures of immediate and delayed memory, verbal fluency and information processing accuracy (age 50) were used to derive measures of resilience in cognitive function-better than predicted cognition, when accounting for experiences of affective symptoms. Factors contributing to resilience in cognitive function were informed by a literature review and included sex, childhood cognitive ability, education, household socio-economic position (SEP), midlife SEP, and APOE genotype. Linear regression and structural equation modelling approaches were used for analyses.Results: Higher childhood cognitive ability, educational level, midlife SEP and female sex contributed to better than predicted cognitive function in relation to affective symptoms (i.e. resilience), with particularly consistent effects for memory. No effects on resilience were revealed for APOE genotype.Conclusion: Understanding factors contributing to resilience in cognitive function in those with affective symptoms can inform interventions to promote healthy cognitive ageing for those at risk.

中文翻译：

---

整个生命过程中的情感症状和认知功能的适应力。

背景：关于哪些因素可以改变整个生命过程中情感症状与认知功能之间的关系知之甚少。目的：使用美国国家统计局的数据，调查可能有助于认知功能与情感症状相关的多种因素。儿童发育研究对象和方法：使用Malaise量表（23、33、42和50岁）测量成人的情感症状。当考虑到情感症状的经历时，立即和延迟记忆，口语流利性和信息处理准确性（50岁）的量度可用于得出认知功能的复原力量度，其优于预期的认知能力。文献综述提供了有助于认知功能恢复力的因素，包括性别，儿童的认知能力，教育程度，家庭社会经济地位（SEP），中年SEP和APOE基因型。结果：高年级儿童的认知能力，教育水平，中年SEP和女性在情感症状（即弹性）方面的认知功能优于预期，对记忆的影响尤其一致。 。结论：了解具有情感症状的人的认知功能弹性的因素可以为干预措施促进风险人群的健康认知老化提供帮助。儿童时期较高的认知能力，受教育水平，中年SEP和女性在情感症状（即韧性）方面的认知功能要好于预期，对记忆的影响尤其一致。结论：了解具有情感症状的人的认知功能弹性的因素可以为干预措施促进风险人群的健康认知老化提供帮助。童年时较高的认知能力，受教育水平，中年SEP和女性在情感症状（即韧性）方面的认知功能要好于预期，对记忆的影响尤其一致。结论：了解具有情感症状的人的认知功能弹性的因素可以为干预措施促进风险人群的健康认知老化提供帮助。