Background: Adult overweight is a potential bladder cancer (BC) risk factor, but little is known about size earlier in life.Aim: To investigate if birth weight, childhood body mass index (BMI), height and growth are associated with adult BC.Subjects and methods: Anthropometric information from birth and ages 7-13 on 315,763 individuals born 1930-1989 in the Copenhagen School Health Records Register was linked to national registers. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox regression.Results: 1145 individuals (839 men) were diagnosed with BC. Sex differences were not detected. Childhood BMI had positive associations and height had inverse associations with BC; at age 13, HR = 1.10 (95% CI: 1.02-1.18) per BMI z-score and HR = 0.94 (95% CI: 0.89-1.00) per height z-score. A pattern of above-average increases in BMI from 7 to 13 years had higher hazards of BC than average increases. Above-average growth in height was not significantly associated with BC. Compared with birth weights of 3.5 kg, low (2.5 kg) and high (4.5 kg) values were associated with increased hazards of BC; HR = 1.26 (95% CI: 1.01-1.58) and HR = 1.36 (95% CI: 1.09-1.70), respectively.Conclusions: A high BMI, a short height, excess BMI gain in childhood and low and high birth weights are associated with increased hazards of BC.

中文翻译：

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生命早期的体型及其与成人膀胱癌的关系。

背景：成人超重是潜在的膀胱癌（BC）危险因素，但对于生命早期的大小知之甚少。目的：研究出生体重，儿童体重指数（BMI），身高和成长是否与成人BC相关。受试者和方法：哥本哈根学校健康记录登记册中19,30-1989年出生的315,763个人的出生年龄和7-13岁年龄段的人体测量学信息已与国家登记册相关联。通过Cox回归评估危险比（HR）和95％置信区间（CI）。结果：1145名患者（839名男性）被诊断出患有BC。未发现性别差异。儿童BMI与BC呈正相关，身高与BC呈负相关。在13岁时，每个BMI z分数HR = 1.10（95％CI：1.02-1.18），每个身高z分数HR = 0.94（95％CI：0.89-1.00）。从7到13年，BMI出现高于平均水平的增长，其BC的危害要高于平均水平。身高高于平均水平的增长与BC无关。与3.5千克出生体重相比，低（2.5千克）和高（4.5千克）值会增加BC的危害。HR = 1.26（95％CI：1.01-1.58）和HR = 1.36（95％CI：1.09-1.70）。结论：高BMI，矮身高，儿童时期BMI增高以及低体重和高体重分别是与BC危害增加有关。