Transcription factor p53 is activated in response to numerous stress stimuli in order to promote repair and survival or death of abnormal cells. For decades, regulatory mechanisms and downstream targets that execute the many biological functions of tumor suppressor p53 largely focused on the products of protein coding genes. Recently, an entirely new class of molecules, termed long non-coding RNAs (lncRNAs), were discovered as key regulatory players in shaping p53 activity and biological outcomes. Many p53-regulated lncRNAs are now reported to either directly or indirectly intervene in p53-regulatory networks, generally in fine-tuning p53’s tumor surveillance program. Recent studies reveal that signals that converge upon p53 to regulate its activity, and molecules that implement downstream p53-response, include both proteins and lncRNAs. In this review, we discuss the non-proteomic component of p53-regulatory networks, focusing on lncRNAs regulated by p53 and/or that regulate p53 activity, and their impact on biological outcomes.

转录因子p53响应大量应激刺激而被激活，以促进异常细胞的修复，存活或死亡。数十年来，执行肿瘤抑制因子p53的许多生物学功能的调控机制和下游目标主要集中在蛋白质编码基因的产物上。最近，发现了一类全新的分子，称为长非编码RNA（lncRNA），是塑造p53活性和生物学结果的关键调控因素。据报道，许多p53调控的lncRNA直接或间接干预p53调控网络，通常是在微调p53的肿瘤监测程序中。最近的研究表明，聚集在p53上以调节其活性的信号以及实现下游p53应答的分子包括蛋白质和lncRNA。