Abstract

An efficient catalytic system comprising of Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe –for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, 3 has been developed. Air stable alkyl phosphonium salt, [(t-Bu)₃Ph]BF₄ was found to be vital for the activation of 3- chloroisochromen-1-ones, 1 in regio-selective Heck coupling reactions. The technique has additionally been reached out to typharin, penicilisorin and artemidin analogs.

中文翻译：

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Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe 催化 Heck 偶联合成 3-Alkenyl-1H-Isochromen-1-Ones

一种由 Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe 组成的高效催化系统——用于合成 3-烯基异色烯-1-酮, 3 中的 Heck 偶联。空气稳定的烷基鏻...