ABSTRACT

Association of signal transducer and activator of transcription 4 (STAT4) gene rs7574865, rs10168266 polymorphisms with systemic lupus erythematosus (SLE) risk remains unclear. A meta-analysis was conducted on the correlation between rs7574865, rs10168266 polymorphisms and SLE. Twenty-six studies were recruited in our study (17,389 patients and 29,273 controls). For rs7574865, results showed significant associations between T allele and SLE susceptibility in overall population, Asians and Europeans (OR=1.557, 95%CI: 1.505-1.611, P<0.001; OR=1.557, 95%CI: 1.498-1.661, P<0.001; OR=1.548, 95%CI: 1.474-1.625, P<0.001). Significant associations of genotypes TT, GT, TT+TG and SLE risk were observed in general subjects, Asians and Europeans (all P<0.001). Regarding rs10168266, increased T allele frequencies were detected in overall SLE cases and those from Asian origin (OR=1.532, 95%CI: 1.440-1.631, P<0.001; OR=1.575, 95%CI: 1.445-1.717, P<0.001). The overall data showed that TT genotype, CT genotype and TT+CT genotype were significantly correlated with SLE (all P < 0.001). In conclusion, the present study verified strong association of STAT4 gene rs7574865, rs10168266 polymorphisms and SLE susceptibility.

摘要

信号转导和转录激活因子 4 (STAT4) 基因 rs7574865、rs10168266 多态性与系统性红斑狼疮 (SLE) 风险的关联仍不清楚。对rs7574865、rs10168266多态性与SLE之间的相关性进行了荟萃分析。我们的研究招募了 26 项研究（17,389 名患者和 29,273 名对照）。对于 rs7574865，结果显示 T 等位基因和 SLE 易感性在整个人群、亚洲人和欧洲人之间存在显着关联（OR=1.557，95%CI：1.505-1.611，P<0.001；OR=1.557，95%CI：1.418-1.66 <0.001；OR=1.548，95%CI：1.474-1.625，P<0.001）。在一般受试者、亚洲人和欧洲人中观察到基因型 TT、GT、TT+TG 和 SLE 风险的显着关联（所有 P<0.001）。关于rs10168266，在整体 SLE 病例和亚洲血统病例中检测到 T 等位基因频率增加（OR=1.532，95%CI：1.440-1.631，P<0.001；OR=1.575，95%CI：1.445-1.717，P<0.001）。总体数据显示TT基因型、CT基因型和TT+CT基因型与SLE显着相关（均P < 0.001）。总之，本研究证实了 STAT4 基因 rs7574865、rs10168266 多态性与 SLE 易感性之间的强关联。