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Plant-based stearidonic acid as sustainable source of omega-3 fatty acid with functional outcomes on human health
Critical Reviews in Food Science and Nutrition ( IF 7.3 ) Pub Date : 2020-05-20 , DOI: 10.1080/10408398.2020.1765137
P Prasad 1, 2 , P Anjali 1, 2 , R V Sreedhar 1, 2
Affiliation  

Abstract

Dietary omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) like eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) are known to be potent biological regulators with therapeutic and preventive effects on human health. Many global health organizations have recommended consuming marine based omega-3 sources for neonatal brain development and reducing the risk of various chronic diseases. However, due to concerns regarding the origin, sustainable supply and safety of the marine sources, alternative n-3 PUFA sources are being explored. Recently, plant-based omega-3 sources are gaining much importance because of their sustainable supply and dietary acceptance. α-linolenic acid (ALA, 18:3n-3) rich seed oils are the major omega-3 fatty acid source available for human consumption. But, efficiency of conversion of ALA to n-3 LC-PUFAs in humans is limited due to a rate-limiting step in the n-3 pathway catalyzed by Δ6-desaturase. Botanical stearidonic acid (SDA, 18:4n-3) rich oils are emerging as a sustainable omega-3 source with efficient conversion rate to n-3 LC-PUFA especially to EPA, as it bypasses the Δ6-desaturase rate limiting step. Several recent studies have identified the major plant sources of SDA and explored its potential health benefits and preventive roles in inflammation, cardiovascular disease (CVD) and cancer. This systematic review summarizes the current state of knowledge on the sources, nutraceutical roles, food-based applications and the future perspectives of botanical SDA.



中文翻译:

基于植物的硬脂酸作为omega-3脂肪酸的可持续来源,对人体健康具有功能性作用

摘要

日粮中的ω-3长链多不饱和脂肪酸(n-3 LC-PUFA),如二十碳五烯酸(EPA,20:5n-3)和二十二碳六烯酸(DHA,22:6n-3)是有效的生物调节剂,具有治疗作用以及对人类健康的预防作用。许多全球卫生组织建议食用海洋来源的omega-3来源来促进新生儿大脑发育,并降低各种慢性疾病的风险。但是,由于对海洋资源的来源,可持续供应和安全的担忧,正在研究其他n-3 PUFA来源。最近,基于植物的omega-3来源由于其可持续的供应和饮食接受而变得越来越重要。富含α-亚麻酸(ALA,18:3n-3)的种子油是可用于人类食用的主要omega-3脂肪酸来源。但,由于Δ6-去饱和酶催化的n-3途径中的限速步骤,限制了人类将ALA转化为n-3 LC-PUFA的效率。富含植物硬脂酸(SDA,18:4n-3)的油正在成为一种可持续的omega-3来源,它绕过Δ6-去饱和酶限速步骤,可高效转化为n-3 LC-PUFA(尤其是EPA)。最近的几项研究已经确定了SDA的主要植物来源,并探索了其潜在的健康益处以及在炎症,心血管疾病(CVD)和癌症中的预防作用。这篇系统的综述总结了有关植物SDA的来源,营养作用,基于食物的应用以及未来前景的知识的现状。富含植物硬脂酸(SDA,18:4n-3)的油正在成为一种可持续的omega-3来源,它绕过Δ6-去饱和酶限速步骤,可高效转化为n-3 LC-PUFA(尤其是EPA)。最近的几项研究已经确定了SDA的主要植物来源,并探索了其潜在的健康益处以及在炎症,心血管疾病(CVD)和癌症中的预防作用。这篇系统的综述总结了有关植物SDA的来源,营养作用,基于食物的应用以及未来前景的知识的现状。富含植物硬脂酸(SDA,18:4n-3)的油正以可持续的omega-3来源出现,它可以有效地转化为n-3 LC-PUFA(尤其是EPA),因为它绕过了Δ6-去饱和酶速率限制步骤。最近的几项研究已经确定了SDA的主要植物来源,并探索了其潜在的健康益处以及在炎症,心血管疾病(CVD)和癌症中的预防作用。这篇系统的综述总结了有关植物SDA的来源,营养作用,基于食物的应用以及未来前景的知识的现状。最近的几项研究已经确定了SDA的主要植物来源,并探索了其潜在的健康益处以及在炎症,心血管疾病(CVD)和癌症中的预防作用。这篇系统的综述总结了有关植物SDA的来源,营养作用,基于食物的应用以及未来前景的知识的现状。最近的几项研究已经确定了SDA的主要植物来源,并探索了其潜在的健康益处以及在炎症,心血管疾病(CVD)和癌症中的预防作用。这篇系统的综述总结了有关植物SDA的来源,营养作用,基于食物的应用以及未来前景的知识的现状。

更新日期:2020-05-20
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