The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in recent years has indicated that metabolic reprogramming is closely interrelated with the regulation of redox homeostasis, suggesting that the disruption of NRF2 signaling might represent a valid therapeutic strategy against a variety of solid and hematologic cancers. These aspects will be the focus of the present review.

中文翻译：

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NRF2 / KEAP1轴在肿瘤代谢调控中的作用：机制和治疗观点。

NRF2 / KEAP1途径是基本的信号传导级联，通过诱导复杂的转录程序来控制多种细胞保护性反应，最终使癌细胞对氧化，代谢和治疗压力具有抵抗力。有趣的是，近年来积累的证据表明，代谢重编程与氧化还原稳态的调节密切相关，这表明NRF2信号的破坏可能代表针对多种实体和血液癌症的有效治疗策略。这些方面将是本次审查的重点。