Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki–Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones. Moreover, cascade cyclocarbopalladation, followed by the reaction with 2-alkynyltrifluoroacetanilides, accomplished a double cyclization to afford challenging 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones bearing a 3-indolyl substituent through aminopalladation/reductive elimination.

中文翻译：

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钯催化的芳基和3-吲哚基取代的4-亚甲基-3,4-二氢异喹啉-1（2H）-的区域和立体选择性合成。

容易获得的含芳基碘基团的芳基/烷基取代的炔丙基酰胺的级联环碳缩合反应，然后将Suzuki-Miyaura与芳基硼酸偶合，可实现区域和立体选择性合成四取代的4-亚甲基-3,4-二氢异喹啉-1 （2 H）-个。此外，级联环羰缩钯反应，然后与2-炔基三氟乙酰苯胺反应，完成了双环化反应，从而通过氨基palpalation /还原消除作用，使带有3-吲哚基取代基的4-亚甲基-3,4-二氢异喹啉-1（2 H）-具有挑战性。