Pharmacological studies were performed in mice on the methanol extract of Tinospora crispa (TC), and of its hexane (HF) and chloroform (CF) fractions. Significant antinociceptive activity was observed for TC, HF, and CF in the acetic acid‐induced writhing and formalin‐induced paw licking tests. Anxiolytic and antidepressant activities were assessed using the open field, hole board, and elevated plus maze (EPM) tests. TC, HF, and CF demonstrated a significant decrease in spontaneous locomotor activity. They also showed an increase in the number of head‐dippings in the hole‐board test, suggesting decreased fearfulness. TC, and most of its fractions, showed a significant increase of the time spent in the opened arm of the EPM, indicating reduced anxiety. This study provides some support to explain the traditional use of T. crispa as a remedy for pain.

中文翻译：

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Tinosporacrispa的镇痛、抗焦虑和抗抑郁活性的药理学研究

对小鼠的药理研究是对卷尾蒌 (TC) 及其己烷 (HF) 和氯仿 (CF) 馏分的甲醇提取物进行的。在乙酸诱导的扭体和福尔马林诱导的舔爪试验中观察到 TC、HF 和 CF 具有显着的镇痛活性。使用开放场、洞板和高架十字迷宫 (EPM) 测试评估抗焦虑和抗抑郁活性。TC、HF 和 CF 显示自发运动活动显着减少。他们还表明在洞板测试中头部倾斜的次数有所增加，这表明恐惧减少了。TC 及其大部分组分显示在 EPM 的张开臂上花费的时间显着增加，表明焦虑减少。这项研究为解释 T.crispa 作为止痛药的传统用途提供了一些支持。