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Dammarane sapogenins attenuates stress‐induced anxiety‐like behaviors by upregulating ERK / CREB / BDNF pathways
Phytotherapy Research ( IF 6.1 ) Pub Date : 2020-05-19 , DOI: 10.1002/ptr.6713
Ning Jiang 1 , Haixia Wang 1 , Jingwei Lv 1 , Qiong Wang 2 , Cong Lu 3 , Yujiao Li 2 , Xinmin Liu 1
Affiliation  

Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic‐like effects of DS in a mouse model of chronic social defeat stress (CSDS). DS (40 and 80 mg/kg) significantly ameliorated social avoidance and anxiety‐like behavior in four test models of CSDS, showing increased time in the interaction zone in the social interaction test and in the center of the field in the open field test, an increased percentage of entries and open arm time in the elevated plus maze, and reduced latency to eat in the novelty‐suppressed feeding test. Biochemical analyses showed that DS significantly reduced serum corticosterone levels and increased brain concentration of neurotransmitter 5‐HT and noradrenaline in CSDS mice. Treatment with DS significantly upregulated BDNF (brain‐derived neurotrophic factor), p‐CREB/CREB and p‐ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. Collectively, these results suggest that DS exerts anxiolytic‐like effects in CSDS model mice and the action is mediated, at least in part, by modulating the HPA (hypothalamic–pituitary–adrenal) axis and monoamine neurotransmitter levels, and via ERK/CREB/BDNF signaling pathway.

中文翻译:


达玛烷皂苷元通过上调 ERK / CREB ​​/ BDNF 通路来减轻压力诱发的焦虑样行为



达玛烷皂苷元(DS)是人参总皂苷碱解而得的提取物,具有较高的药理活性和比人参皂苷更高的生物利用度。本研究旨在研究 DS 在慢性社交失败应激 (CSDS) 小鼠模型中的抗焦虑样作用。 DS(40 和 80 mg/kg)显着改善了 CSDS 的四种测试模型中的社交回避和焦虑样行为,显示出社交互动测试中互动区的时间增加以及开放场地测试中场地中心的时间增加,增加了高架十字迷宫中的进入百分比和开臂时间,并减少了新奇抑制喂养测试中进食的潜伏期。生化分析表明,DS 显着降低了 CSDS 小鼠的血清皮质酮水平,并增加了神经递质 5-HT 和去甲肾上腺素的脑浓度。 DS治疗显着上调了CSDS小鼠海马和前额皮质中的BDNF(脑源性神经营养因子)、p-CREB/CREB和p-ERK1/2/ERK1/2蛋白表达。总的来说,这些结果表明 DS 在 CSDS 模型小鼠中发挥抗焦虑样作用,并且该作用至少部分是通过调节 HPA(下丘脑 - 垂体 - 肾上腺)轴和单胺神经递质水平以及通过 ERK/CREB/ 介导的。 BDNF 信号通路。
更新日期:2020-05-19
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